WFRF:(Kannisto P)
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- Zach, D.Karolinska Institutet (author)
Time to extend the indication for sentinel node biopsy in vulvar cancer? Results from a prospective nationwide Swedish study
- Article/chapterEnglish2023
Publisher, publication year, extent ...
- BMJ PUBLISHING GROUP,2023
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/332312
- https://gup.ub.gu.se/publication/332312URI
- https://doi.org/10.1136/ijgc-2023-004790DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-199321URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:154134344URI
Supplementary language notes
- Language:English
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- SwePubSwePub
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- Funding Agencies|Swedish Society for Gynecologic Oncology, SSGO
- ObjectiveTo assess detection rates and negative predictive values of sentinel node biopsy in vulvar squamous cell carcinoma with tumors >= 4 cm, multifocal tumors, and in locally recurrent disease.MethodsBetween December 2019 and December 2022, patients with vulvar squamous cell carcinoma with tumors >= 4 cm (group 1), multifocal tumors (group 2), or a first local recurrence without or with previous groin treatment (groups 3 and 4, respectively) were included in a prospective, nationwide multicenter interventional pilot study. The participants underwent a sentinel node biopsy followed by inguinofemoral lymph node dissection. Detection rates, negative predictive values, the proportion of micrometastases, and isolated tumor cells were determined separately for each group.ResultsIn all, 64 women were included, 36 women in group 1 (56%), and 17 women in group 2 (27%). Due to the small number and heterogeneity of the 11 women in groups 3 and 4, they were excluded from further analyses. In groups 1 and 2, 25 women (47%) were diagnosed with node-positive disease, and in 16 women (64%) only in the sentinel nodes. The detection rates varied between 94.1-100% per patient and 84.1-85.3% per groin. No false-negative sentinel nodes were identified, giving a negative predictive value of 100% for group 1 (95% CI 91.2% to 100%) and for group 2 (95% CI 83.9% to 100%). Of the node-positive patients, 32% had micrometastasis or isolated tumor cells only. One third of the metastases were detected by ultrastaging. In 27% of the non-mapping groins, metastases were found in the lymphadenectomy specimen, and in 75% the metastases showed extranodal growth.ConclusionIn this small cohort of patients, we provide further data that may widen the indication of the sentinel node technique to women with tumors >= 4 cm and multifocal tumors.Trial registration numberNCT04147780.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- vulvar and vaginal cancer
- sentinel lymph node
- vulvar neoplasms
- squamous-cell carcinoma
- breast-cancer
- dissection
- complications
- metastasis
- guidelines
- management
- morbidity
- survival
- surgery
- Oncology
- Obstetrics & Gynecology
- vulvar and vaginal cancer; sentinel lymph node; vulvar neoplasms
Added entries (persons, corporate bodies, meetings, titles ...)
- Bohlin Stenström, KatjaGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology,Univ Gothenburg, Sweden (author)
- Kannisto, P.Lund Univ Hosp, Sweden (author)
- Moberg, L.Skanes Univ Sjukhus Lund, Sweden (author)
- Kjölhede, PrebenLinköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, Kvinnokliniken US(Swepub:liu)prekj14 (author)
- Karolinska InstitutetInstitutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi (creator_code:org_t)
Related titles
- In:International Journal of Gynecological Cancer: BMJ PUBLISHING GROUP33:12, s. 1845-18521048-891X1525-1438
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