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Causal Association ...
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Goodman, Matthew O.Broad Institute,Brigham and Women's Hospital / Harvard Medical School
(author)
Causal Association Between Subtypes of Excessive Daytime Sleepiness and Risk of Cardiovascular Diseases
- Article/chapterEnglish2023
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/332699
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https://gup.ub.gu.se/publication/332699URI
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https://doi.org/10.1161/JAHA.122.030568DOI
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https://lup.lub.lu.se/record/1959934b-fa64-4819-926d-d50b8143be72URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND: Excessive daytime sleepiness (EDS), experienced in 10% to 20% of the population, has been associated with cardiovascular disease and death. However, the condition is heterogeneous and is prevalent in individuals having short and long sleep duration. We sought to clarify the relationship between sleep duration subtypes of EDS with cardiovascular outcomes, accounting for these subtypes. METHODS AND RESULTS: We defined 3 sleep duration subtypes of excessive daytime sleepiness: normal (6-9hours), short (<6hours), and long (>9hours), and compared these with a nonsleepy, normal-sleep-duration reference group. We analyzed their associations with incident myocardial infarction (MI) and stroke using medical records of 355901 UK Biobank participants and performed 2-sample Mendelian randomization for each outcome. Compared with healthy sleep, long-sleep EDS was associated with an 83% increased rate of MI (hazard ratio, 1.83 [95% CI, 1.21-2.77]) during 8.2-year median follow-up, adjusting for multiple health and sociodemographic factors. Mendelian randomization analysis provided supporting evidence of a causal role for a genetic long-sleep EDS subtype in MI (inverse-variance weighted β=1.995, P=0.001). In contrast, we did not find evidence that other subtypes of EDS were associated with incident MI or any associations with stroke (P>0.05). CONCLUSIONS: Our study suggests the previous evidence linking EDS with increased cardiovascular disease risk may be primarily driven by the effect of its long-sleep subtype on higher risk of MI. Underlying mechanisms remain to be investigated but may involve sleep irregularity and circadian disruption, suggesting a need for novel interventions in this population.
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Dashti, Hassan S.Massachusetts General Hospital,Broad Institute
(author)
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Lane, Jacqueline M.Broad Institute,Brigham and Women's Hospital / Harvard Medical School,Massachusetts General Hospital
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Windred, Daniel P.Monash University
(author)
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Burns, AngusMonash University,Broad Institute,Massachusetts General Hospital
(author)
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Jones, Samuel E.University of Exeter,University of Helsinki
(author)
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Sofer, TamarBrigham and Women's Hospital / Harvard Medical School,Harvard University
(author)
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Purcell, Shaun M.Brigham and Women's Hospital / Harvard Medical School,Broad Institute
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Zhu, XiaofengCase Western Reserve University
(author)
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Ollila, Hanna M.University of Helsinki,Massachusetts General Hospital,Broad Institute
(author)
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Kyle, Simon D.University of Oxford
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Spiegelhalder, Kai
(author)
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Peker, Yüksel,1961Lund University,Lunds universitet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Brigham and Women's Hospital / Harvard Medical School,University of Pittsburgh,Sahlgrenska Academy(Swepub:lu)yu6542pe
(author)
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Huang, TianyiBrigham and Women's Hospital / Harvard Medical School
(author)
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Cain, Sean W.Monash University
(author)
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Phillips, Andrew J.K.Monash University
(author)
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Saxena, RichaBroad Institute,Massachusetts General Hospital
(author)
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Rutter, Martin K.Manchester Academic Health Science Centre,University of Manchester
(author)
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Redline, SusanBrigham and Women's Hospital / Harvard Medical School
(author)
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Wang, HemingBroad Institute,Brigham and Women's Hospital / Harvard Medical School
(author)
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Broad InstituteBrigham and Women's Hospital / Harvard Medical School
(creator_code:org_t)
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In:Journal of the American Heart Association12:242047-9980
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Goodman, Matthew ...
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Dashti, Hassan S ...
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Lane, Jacqueline ...
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Windred, Daniel ...
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Burns, Angus
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Jones, Samuel E.
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Sofer, Tamar
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Purcell, Shaun M ...
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Zhu, Xiaofeng
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Ollila, Hanna M.
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Kyle, Simon D.
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Spiegelhalder, K ...
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Peker, Yüksel, 1 ...
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Huang, Tianyi
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Cain, Sean W.
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Phillips, Andrew ...
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Saxena, Richa
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Rutter, Martin K ...
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Redline, Susan
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Wang, Heming
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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University of Gothenburg
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Lund University