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Biomarkers in trans...
Biomarkers in transposition of the great arteries after arterial switch operation: A pilot trial with deep phenotyping
- Article/chapterEnglish2024
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LIBRIS-ID:oai:gup.ub.gu.se/332703
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https://gup.ub.gu.se/publication/332703URI
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https://doi.org/10.1016/j.ijcard.2023.131652DOI
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Introduction: Transposition of the great arteries (TGA) is a cyanotic congenital heart defect for which the arterial switch operation (ASO) is the preferred surgical repair. This study wanted to investigate whether a panel of biomarkers could identify morphologic as well as hemodynamic changes obtained by cardiac magnetic resonance (CMR). Methods: Forty-four adult patients were included. Blood samples were collected to measure a broad range of biomarkers (galectin-3, ST2, GDF-15, PINP, ICTP, PIIINP, IGF-1, NT-proBNP, and hs-Tn). CMR was performed at rest and during exercise to assess cardiac function and morphology. Explorative statistics were performed between biomarker levels and CMR findings. Results: All patients were asymptomatic. While galectin-3, GDF-15, and NT-proBNP levels were within normal ranges, increased ST2, PINP, PIIINP, and ICTP levels were found in 20.5%, 34.1%, 45.5%, and 27.3% of patients, respectively. Moreover, 3 and 2 patients, respectively, showed elevated IGF-1 and hs-Tn levels. Although the ejection fraction of both ventricles was within normal limits, impaired cardiac reserve was found in 20 and 25% of patients for left and right ventricle, respectively. CMR revealed no evidence of diffuse interstitial fibrosis, while 4 patients showed focal ischemic scarring. However, no significant associations between serum biomarkers and CMR data could be detected. Conclusion: The results suggest that in asymptomatic ASO-repaired TGA patients serum level biomarkers are elevated and that this increase is not associated with morphological changes nor with a decreased cardiac reserve. Further study with larger sample sizes is required to draw conclusions with greater confidence.
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Santens, Béatrice
(author)
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De Meester, Pieter
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Troost, Els
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Claus, Piet
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Moons, Philip,1968Gothenburg University,Göteborgs universitet,Institutionen för vårdvetenskap och hälsa,Institute of Health and Care Sciences(Swepub:gu)xmooph
(author)
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Bogaert, Jan
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Vermeersch, Pieter
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Van De Bruaene, Alexander
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Budts, Werner
(author)
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Göteborgs universitetInstitutionen för vårdvetenskap och hälsa
(creator_code:org_t)
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In:International Journal of Cardiology3970167-52731874-1754
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Conings, Nele
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Santens, Béatric ...
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De Meester, Piet ...
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Troost, Els
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Claus, Piet
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Moons, Philip, 1 ...
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Bogaert, Jan
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Vermeersch, Piet ...
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Van De Bruaene, ...
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Budts, Werner
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- MEDICAL AND HEALTH SCIENCES
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University of Gothenburg