A1Meighted Composite of Endodontic Inflammatory Disease is Linked to a First Myocardial Infarction

• Purpose: To explore a weighted composite of endodontic inflammatory disease (ED) as a risk factor for suffering a first myocardial infarction (MI).Materials and Methods: Seven tooth-specific conditions related to EID were assessed radiographically in 797 patients suffering a first MI and 796 controls. A weighted composite of EID was calculated as the sum of all teeth, excluding third molars. Using maximum likelihood estimation, each condition was assigned a specific weight. Wth multivariable condi-tional regression, EIDvariables, periodontal disease, and missing teeth were assessed as predictors of a first MLResults: Periodontal disease (OR 1.38; 95% CI 1.13-1.69, p =0.0016) and missing teeth (OR 1.03; 95% CI 1.002-1.05, p =0.034) were related to the risk of a first MI, while none of the ED-related conditions individually were. However, when assessed as an aggregate, a weighted composite of ED (OR 1.97; 95% CI 1.23-3.17, p =0.0050) and periodontal disease (OR 1.34; 95% CI 1.09-1.63, p =0.0046) was associated with the risk of ML Missing teeth did not remain a statistically sig-nificant predictor of MI in the final model.Condusions: A weighted composite of ED was associated with the risk of MI and strengthens the evidence for a direst connection between oral inflammatory diseases and cardiovascular disorders.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Odontologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Dentistry (hsv//eng)

Nyckelord

cardiovascular disease(s)

endodontics

inflammation

periodontal

disease(s)

riskfactors(s)

systemic health/disease

root-canal treatment

apical periodontitis

dental-health

association

radiography

accuracy

Dentistry

Oral Surgery & Medicine

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)