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Unraveling Neuro-Pr...
Unraveling Neuro-Proteogenomic Landscape and Therapeutic Implications for Human Behaviors and Psychiatric Disorders.
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Repetto, Linda (author)
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Chen, Jiantao (author)
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Yang, Zhijian (author)
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show more...
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Zhai, Ranran (author)
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Timmers, Paul R H J (author)
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Li, Ting (author)
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Twait, Emma L (author)
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May-Wilson, Sebastian (author)
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Muckian, Marisa D (author)
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Prins, Bram P (author)
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Png, Grace (author)
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Kooperberg, Charles (author)
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Johansson, Åsa (author)
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Hillary, Robert F (author)
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Wheeler, Eleanor (author)
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- Pan, Lu (author)
- Karolinska Institutet
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He, Yazhou (author)
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Klasson, Sofia (author)
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Ahmad, Shahzad (author)
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Peters, James E (author)
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Gilly, Arthur (author)
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Karaleftheri, Maria (author)
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Tsafantakis, Emmanouil (author)
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Haessler, Jeffrey (author)
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Gyllensten, Ulf (author)
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Harris, Sarah E (author)
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Wareham, Nicholas J (author)
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Göteson, Andreas (author)
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Lagging, Cecilia (author)
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Ikram, Mohammad Arfan (author)
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van Duijn, Cornelia M (author)
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Jern, Christina (author)
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- Landén, Mikael, 1966 (author)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Langenberg, Claudia (author)
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Deary, Ian J (author)
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Marioni, Riccardo E (author)
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Enroth, Stefan (author)
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Reiner, Alexander P (author)
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Dedoussis, George (author)
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Zeggini, Eleftheria (author)
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Butterworth, Adam S (author)
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Mälarstig, Anders (author)
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Wilson, James F (author)
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Navarro, Pau (author)
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Shen, Xia (author)
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(creator_code:org_t)
- Research Square Platform LLC, 2023
- 2023
- English.
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In: Nature Portfolio. - : Research Square Platform LLC.
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.2...
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Abstract
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- Understanding the genetic basis of neuro-related proteins is essential for dissecting the molecular basis of human behavioral traits and the disease etiology of neuropsychiatric disorders. Here, the SCALLOP Consortium conducted a genome-wide association meta-analysis of over 12,500 individuals for 184 neuro-related proteins in human plasma. The analysis identified 117 cis-regulatory protein quantitative trait loci (cis-pQTL) and 166 trans-pQTL. The mapped pQTL capture on average 50% of each protein's heritability. Mendelian randomization analyses revealed multiple proteins showing potential causal effects on neuro-related traits such as sleeping, smoking, feelings, alcohol intake, mental health, and psychiatric disorders. Integrating with established drug information, we validated 13 out of 13 matched combinations of protein targets and diseases or side effects with available drugs, while suggesting hundreds of re-purposing and new therapeutic targets. This consortium effort provides a large-scale proteogenomic resource for biomedical research on human behaviors and other neuro-related phenotypes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Publication and Content Type
- vet (subject category)
- art (subject category)
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- By the author/editor
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Repetto, Linda
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Chen, Jiantao
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Yang, Zhijian
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Zhai, Ranran
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Timmers, Paul R ...
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Li, Ting
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show more...
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Twait, Emma L
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May-Wilson, Seba ...
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Muckian, Marisa ...
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Prins, Bram P
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Png, Grace
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Kooperberg, Char ...
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Johansson, Åsa
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Hillary, Robert ...
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Wheeler, Eleanor
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Pan, Lu
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He, Yazhou
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Klasson, Sofia
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Ahmad, Shahzad
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Peters, James E
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Gilly, Arthur
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Karaleftheri, Ma ...
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Tsafantakis, Emm ...
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Haessler, Jeffre ...
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Gyllensten, Ulf
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Harris, Sarah E
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Wareham, Nichola ...
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Göteson, Andreas
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Lagging, Cecilia
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Ikram, Mohammad ...
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van Duijn, Corne ...
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Jern, Christina
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Landén, Mikael, ...
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Langenberg, Clau ...
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Deary, Ian J
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Marioni, Riccard ...
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Enroth, Stefan
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Reiner, Alexande ...
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Dedoussis, Georg ...
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Zeggini, Elefthe ...
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Butterworth, Ada ...
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Mälarstig, Ander ...
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Wilson, James F
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Navarro, Pau
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Shen, Xia
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
- Nature Portfolio
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Research square
- By the university
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University of Gothenburg
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Karolinska Institutet