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Association of poly...
Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder.
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Amare, Azmeraw T (author)
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Thalamuthu, Anbupalam (author)
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Schubert, Klaus Oliver (author)
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show more...
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Fullerton, Janice M (author)
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Ahmed, Muktar (author)
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Hartmann, Simon (author)
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Papiol, Sergi (author)
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Heilbronner, Urs (author)
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Degenhardt, Franziska (author)
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Tekola-Ayele, Fasil (author)
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Hou, Liping (author)
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Hsu, Yi-Hsiang (author)
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Shekhtman, Tatyana (author)
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Adli, Mazda (author)
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Akula, Nirmala (author)
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Akiyama, Kazufumi (author)
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Ardau, Raffaella (author)
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Arias, Bárbara (author)
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Aubry, Jean-Michel (author)
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Hasler, Roland (author)
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Richard-Lepouriel, Hélène (author)
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Perroud, Nader (author)
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- Backlund, Lena (author)
- Karolinska Institutet
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Bhattacharjee, Abesh Kumar (author)
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Bellivier, Frank (author)
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Benabarre, Antonio (author)
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Bengesser, Susanne (author)
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Biernacka, Joanna M (author)
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Birner, Armin (author)
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Marie-Claire, Cynthia (author)
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Cervantes, Pablo (author)
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Chen, Hsi-Chung (author)
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- Chillotti, Caterina (author)
- Karolinska Institutet
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Cichon, Sven (author)
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Cruceanu, Cristiana (author)
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Czerski, Piotr M (author)
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Dalkner, Nina (author)
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Del Zompo, Maria (author)
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DePaulo, J Raymond (author)
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Étain, Bruno (author)
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Jamain, Stephane (author)
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Falkai, Peter (author)
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Forstner, Andreas J (author)
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- Frisen, Louise (author)
- Karolinska Institutet
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Frye, Mark A (author)
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Gard, Sébastien (author)
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Garnham, Julie S (author)
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Goes, Fernando S (author)
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Grigoroiu-Serbanescu, Maria (author)
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Fallgatter, Andreas J (author)
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Stegmaier, Sophia (author)
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Ethofer, Thomas (author)
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Biere, Silvia (author)
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Petrova, Kristiyana (author)
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Schuster, Ceylan (author)
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Adorjan, Kristina (author)
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Budde, Monika (author)
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Heilbronner, Maria (author)
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Kalman, Janos L (author)
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Kohshour, Mojtaba Oraki (author)
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Reich-Erkelenz, Daniela (author)
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Schaupp, Sabrina K (author)
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Schulte, Eva C (author)
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Senner, Fanny (author)
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Vogl, Thomas (author)
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Anghelescu, Ion-George (author)
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Arolt, Volker (author)
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Dannlowski, Udo (author)
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Dietrich, Detlef (author)
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Figge, Christian (author)
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Jäger, Markus (author)
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Lang, Fabian U (author)
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Juckel, Georg (author)
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Konrad, Carsten (author)
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Reimer, Jens (author)
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Schmauß, Max (author)
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Schmitt, Andrea (author)
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Spitzer, Carsten (author)
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von Hagen, Martin (author)
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Wiltfang, Jens (author)
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Zimmermann, Jörg (author)
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Andlauer, Till F M (author)
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Fischer, Andre (author)
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Bermpohl, Felix (author)
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Ritter, Philipp (author)
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Matura, Silke (author)
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Gryaznova, Anna (author)
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Falkenberg, Irina (author)
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Yildiz, Cüneyt (author)
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Kircher, Tilo (author)
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Schmidt, Julia (author)
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Koch, Marius (author)
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Gade, Kathrin (author)
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Trost, Sarah (author)
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Haussleiter, Ida S (author)
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Lambert, Martin (author)
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Rohenkohl, Anja C (author)
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Kraft, Vivien (author)
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Grof, Paul (author)
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Hashimoto, Ryota (author)
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Hauser, Joanna (author)
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Herms, Stefan (author)
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Hoffmann, Per (author)
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Jiménez, Esther (author)
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Kahn, Jean-Pierre (author)
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Kassem, Layla (author)
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Kuo, Po-Hsiu (author)
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Kato, Tadafumi (author)
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Kelsoe, John (author)
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Kittel-Schneider, Sarah (author)
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Ferensztajn-Rochowiak, Ewa (author)
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König, Barbara (author)
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Kusumi, Ichiro (author)
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Laje, Gonzalo (author)
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- Landén, Mikael, 1966 (author)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Lavebratt, Catharina (author)
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Leboyer, Marion (author)
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Leckband, Susan G (author)
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Tortorella, Alfonso (author)
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- Manchia, Mirko (author)
- Karolinska Institutet
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- Martinsson, Lina (author)
- Karolinska Institutet
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McCarthy, Michael J (author)
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McElroy, Susan (author)
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Colom, Francesc (author)
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- Millischer, Vincent (author)
- Karolinska Institutet
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Mitjans, Marina (author)
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Mondimore, Francis M (author)
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Monteleone, Palmiero (author)
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Nievergelt, Caroline M (author)
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Nöthen, Markus M (author)
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Novák, Tomas (author)
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O'Donovan, Claire (author)
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Ozaki, Norio (author)
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Pfennig, Andrea (author)
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Pisanu, Claudia (author)
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Potash, James B (author)
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Reif, Andreas (author)
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Reininghaus, Eva (author)
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Rouleau, Guy A (author)
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Rybakowski, Janusz K (author)
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Schalling, Martin (author)
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Schofield, Peter R (author)
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Schweizer, Barbara W (author)
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Severino, Giovanni (author)
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Shilling, Paul D (author)
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Shimoda, Katzutaka (author)
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Simhandl, Christian (author)
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Slaney, Claire M (author)
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Squassina, Alessio (author)
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Stamm, Thomas (author)
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Stopkova, Pavla (author)
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Maj, Mario (author)
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Turecki, Gustavo (author)
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Vieta, Eduard (author)
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Veeh, Julia (author)
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Witt, Stephanie H (author)
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Wright, Adam (author)
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Zandi, Peter P (author)
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Mitchell, Philip B (author)
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Bauer, Michael (author)
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Alda, Martin (author)
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Rietschel, Marcella (author)
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McMahon, Francis J (author)
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Schulze, Thomas G (author)
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Clark, Scott R (author)
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Baune, Bernhard T (author)
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Molecular psychiatry. - 1476-5578. ; 28, s. 5251-5261
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
Close
- Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental healthdisorder that affects about 1% of the population worldwide. Nevertheless, lithium is not consistently effective, with only 30% of patients showing a favorable response to treatment. To provide personalized treatment options for bipolar patients, it is essential to identify prediction biomarkers such as polygenic scores. In this study, we developed a polygenic score for lithium treatment response (Li+PGS) in patients with BD. To gain further insights into lithium's possible molecular mechanism of action, we performed a genome-wide gene-based analysis. Using polygenic score modeling, via methods incorporating Bayesian regression and continuous shrinkage priors, Li+PGS was developed in the International Consortium of Lithium Genetics cohort (ConLi+Gen: N=2367) and replicated in the combined PsyCourse (N=89) and BipoLife (N=102) studies. The associations of Li+PGS and lithium treatment response - defined in a continuous ALDA scale and a categorical outcome (good response vs. poor response) were tested using regression models, each adjusted for the covariates: age, sex, and the first four genetic principal components. Statistical significance was determined at P<0.05. Li+PGS was positively associated with lithium treatment response in the ConLi+Gen cohort, in both the categorical (P=9.8×10-12, R2=1.9%) and continuous (P=6.4×10-9, R2=2.6%) outcomes. Compared to bipolar patients in the 1st decile of the risk distribution, individuals in the 10th decile had 3.47-fold (95%CI: 2.22-5.47) higher odds of responding favorably to lithium. The results were replicated in the independent cohorts for the categorical treatment outcome (P=3.9×10-4, R2=0.9%), but not for the continuous outcome (P=0.13). Gene-based analyses revealed 36 candidate genes that are enriched in biological pathways controlled by glutamate and acetylcholine. Li+PGS may be useful in the development of pharmacogenomic testing strategies by enabling a classification of bipolar patients according to their response to treatment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Amare, Azmeraw T
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Thalamuthu, Anbu ...
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Schubert, Klaus ...
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Fullerton, Janic ...
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Ahmed, Muktar
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Hartmann, Simon
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Papiol, Sergi
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Heilbronner, Urs
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Degenhardt, Fran ...
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Tekola-Ayele, Fa ...
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Hou, Liping
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Hsu, Yi-Hsiang
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Shekhtman, Tatya ...
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Adli, Mazda
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Akula, Nirmala
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Akiyama, Kazufum ...
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Ardau, Raffaella
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Arias, Bárbara
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Aubry, Jean-Mich ...
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Hasler, Roland
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Richard-Lepourie ...
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Perroud, Nader
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Backlund, Lena
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Bhattacharjee, A ...
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Bellivier, Frank
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Benabarre, Anton ...
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Bengesser, Susan ...
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Biernacka, Joann ...
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Birner, Armin
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Marie-Claire, Cy ...
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Cervantes, Pablo
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Chen, Hsi-Chung
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Chillotti, Cater ...
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Cichon, Sven
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Cruceanu, Cristi ...
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Czerski, Piotr M
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Dalkner, Nina
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Del Zompo, Maria
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DePaulo, J Raymo ...
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Étain, Bruno
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Jamain, Stephane
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Falkai, Peter
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Forstner, Andrea ...
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Frisen, Louise
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Frye, Mark A
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Gard, Sébastien
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Garnham, Julie S
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Goes, Fernando S
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Grigoroiu-Serban ...
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Fallgatter, Andr ...
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Stegmaier, Sophi ...
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Ethofer, Thomas
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Biere, Silvia
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Petrova, Kristiy ...
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Schuster, Ceylan
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Adorjan, Kristin ...
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Budde, Monika
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Heilbronner, Mar ...
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Kalman, Janos L
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Kohshour, Mojtab ...
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Reich-Erkelenz, ...
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Schaupp, Sabrina ...
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Schulte, Eva C
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Senner, Fanny
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Vogl, Thomas
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Anghelescu, Ion- ...
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Arolt, Volker
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Dannlowski, Udo
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Dietrich, Detlef
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Figge, Christian
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Jäger, Markus
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Lang, Fabian U
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Juckel, Georg
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Konrad, Carsten
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Reimer, Jens
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Schmauß, Max
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Schmitt, Andrea
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Spitzer, Carsten
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von Hagen, Marti ...
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Wiltfang, Jens
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Zimmermann, Jörg
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Andlauer, Till F ...
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Fischer, Andre
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Bermpohl, Felix
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Ritter, Philipp
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Matura, Silke
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Gryaznova, Anna
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Falkenberg, Irin ...
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Yildiz, Cüneyt
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Kircher, Tilo
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Schmidt, Julia
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Koch, Marius
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Gade, Kathrin
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Trost, Sarah
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Haussleiter, Ida ...
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Lambert, Martin
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Rohenkohl, Anja ...
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Kraft, Vivien
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Grof, Paul
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Hashimoto, Ryota
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Hauser, Joanna
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Herms, Stefan
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Hoffmann, Per
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Jiménez, Esther
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Kahn, Jean-Pierr ...
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Kassem, Layla
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Kuo, Po-Hsiu
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Kato, Tadafumi
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Kelsoe, John
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Kittel-Schneider ...
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Ferensztajn-Roch ...
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König, Barbara
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Kusumi, Ichiro
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Laje, Gonzalo
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Landén, Mikael, ...
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Lavebratt, Catha ...
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Leboyer, Marion
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Leckband, Susan ...
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Tortorella, Alfo ...
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Manchia, Mirko
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Martinsson, Lina
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McCarthy, Michae ...
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McElroy, Susan
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Colom, Francesc
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Millischer, Vinc ...
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Mitjans, Marina
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Mondimore, Franc ...
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Monteleone, Palm ...
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Nievergelt, Caro ...
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Nöthen, Markus M
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Novák, Tomas
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O'Donovan, Clair ...
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Ozaki, Norio
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Pfennig, Andrea
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Pisanu, Claudia
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Potash, James B
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Reif, Andreas
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Reininghaus, Eva
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Rouleau, Guy A
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Rybakowski, Janu ...
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Schalling, Marti ...
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Schofield, Peter ...
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Schweizer, Barba ...
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Severino, Giovan ...
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Shilling, Paul D
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Shimoda, Katzuta ...
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Simhandl, Christ ...
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Slaney, Claire M
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Squassina, Aless ...
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Stamm, Thomas
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Stopkova, Pavla
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Maj, Mario
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Turecki, Gustavo
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Vieta, Eduard
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Veeh, Julia
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Witt, Stephanie ...
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Wright, Adam
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Zandi, Peter P
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Mitchell, Philip ...
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Bauer, Michael
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Alda, Martin
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Rietschel, Marce ...
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McMahon, Francis ...
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Schulze, Thomas ...
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Clark, Scott R
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Baune, Bernhard ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Molecular psychi ...
- By the university
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University of Gothenburg
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Karolinska Institutet