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  • Teunissen, Charlotte EMIRIADE Consortium: Multiomics Interdisciplinary Research Integration to Address Dementia diagnosis, Amsterdam, The Netherlands; Neurochemistry Lab, Department of Laboratory Medicine, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands (author)

Methods to Discover and Validate Biofluid-Based Biomarkers in Neurodegenerative Dementias.

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • Elsevier BV,2023

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/332999
  • https://gup.ub.gu.se/publication/332999URI
  • https://doi.org/10.1016/j.mcpro.2023.100629DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-339558URI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20231114
  • Neurodegenerative dementias are progressive diseases that cause neuronal network breakdown in different brain regions often because of accumulation of misfolded proteins in the brain extracellular matrix, such as amyloids or inside neurons or other cell types of the brain. Several diagnostic protein biomarkers in body fluids are being used and implemented, such as for Alzheimer's disease. However, there is still a lack of biomarkers for co-pathologies and other causes of dementia. Such biofluid-based biomarkers enable precision medicine approaches for diagnosis and treatment, allow to learn more about underlying disease processes, and facilitate the development of patient inclusion and evaluation tools in clinical trials. When designing studies to discover novel biofluid-based biomarkers, choice of technology is an important starting point. But there are so many technologies to choose among. To address this, we here review the technologies that are currently available in research settings and, in some cases, in clinical laboratory practice. This presents a form of lexicon on each technology addressing its use in research and clinics, its strengths and limitations, and a future perspective.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Kimble, Leighann (author)
  • Bayoumy, Sherif (author)
  • Bolsewig, Katharina (author)
  • Burtscher, Felicia (author)
  • Coppens, Salomé (author)
  • Das, Shreyasee (author)
  • Gogishvili, Dea (author)
  • Fernandes Gomes, BárbaraGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xferba (author)
  • Gómez de San José, Nerea (author)
  • Mavrina, Ekaterina (author)
  • Meda, Francisco J,1997Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xgonfr (author)
  • Mohaupt, Pablo (author)
  • Mravinacová, SáraKTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab,MIRIADE Consortium: Multiomics Interdisciplinary Research Integration to Address Dementia diagnosis, Amsterdam, The Netherlands(Swepub:kth)u1utu00u (author)
  • Waury, Katharina (author)
  • Wojdała, Anna Lidia (author)
  • Abeln, Sanne (author)
  • Chiasserini, Davide (author)
  • Hirtz, Christophe (author)
  • Gaetani, Lorenzo (author)
  • Vermunt, Lisa (author)
  • Bellomo, Giovanni (author)
  • Halbgebauer, Steffen (author)
  • Lehmann, Sylvain (author)
  • Månberg, Anna,1985-KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab,MIRIADE Consortium: Multiomics Interdisciplinary Research Integration to Address Dementia diagnosis, Amsterdam, The Netherlands(Swepub:kth)u1g5roxd (author)
  • Nilsson, PeterKTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik,MIRIADE Consortium: Multiomics Interdisciplinary Research Integration to Address Dementia diagnosis, Amsterdam, The Netherlands(Swepub:kth)u1ws88sk (author)
  • Otto, Markus (author)
  • Vanmechelen, Eugeen (author)
  • Verberk, Inge M W (author)
  • Willemse, Eline (author)
  • Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,MIRIADE Consortium: Multiomics Interdisciplinary Research Integration to Address Dementia diagnosis, Amsterdam, The Netherlands; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK; UK Dementia Research Institute at UCL, London, UK; Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong, China; Clear Water Bay; Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA(Swepub:gu)xzethe (author)
  • MIRIADE Consortium: Multiomics Interdisciplinary Research Integration to Address Dementia diagnosis, Amsterdam, The Netherlands; Neurochemistry Lab, Department of Laboratory Medicine, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit, Amsterdam, NetherlandsInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)

Related titles

  • In:Molecular & cellular proteomics : MCP: Elsevier BV22:101535-94841535-9476

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