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  • Hegmar, HannesDivision of Hepatology, Department of Upper GI, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden,Karolinska Univ Hosp, Dept Upper GI, Div Hepatol, Stockholm, Sweden.;Karolinska Inst, Dept Med, Stockholm, Sweden. (författare)

Performance of novel collagen turnover biomarkers to detect increased liver stiffness in MASLD

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • Wiley-Blackwell,2024
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-114613
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-114613URI
  • https://doi.org/10.1111/joim.13813DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-535566URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-206419URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:238959258URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:158830474URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|Cancerfonden
  • BACKGROUND: Cleavage products from collagen formation and degradation hold potential as first-line biomarkers for the risk of advanced fibrosis in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we evaluated the performance of PRO-C3, PRO-C6, C4M, PRO-C18L, and the clinical score ADAPT (age, diabetes, PRO-C3, and platelet count) to detect patients with an LSM >8 kPa or >12 kPa in comparison to the Fibrosis-4 Index (FIB-4).METHODS: Serum from patients with MASLD (n = 269) from six Swedish University Hospitals was analyzed using enzyme-linked immunosorbent assay-based methods. Liver stiffness measurement (LSM) by vibration-controlled transient elastography was performed. The area under the curve (AUC), calibration curves, and net benefit analysis were used.RESULTS: An LSM >8 kPa was found in 108 (40.1%) patients. PRO-C3, PRO-C6, C4M, and PRO-C18L had AUCs ranging from 0.48 to 0.62. ADAPT had the highest AUC (0.73, 95% confidence interval [CI] = 0.67-0.79) to detect patients >8 kPa, compared to FIB-4 (0.71, (95%CI = 0.64-0.77, p = 0.35), and had a higher net benefit compared to FIB-4 from a probability threshold of 15%. FIB-4 and ADAPT performed equally well to detect patients with an LSM >12 kPa, AUC 0.76 versus 0.76, p = 0.93.CONCLUSIONS: ADAPT seems to be marginally better than FIB-4 in identifying patients with an LSM >8 kPa. However, the clinical utility of ADAPT as a first line test is uncertain, especially in low-risk populations. The overall performance of FIB-4 was similar to that of ADAPT in detecting patients with an LSM of >12 kPa. Altogether, the results suggest that ADAPT might be useful to detect earlier stages of fibrosis in MASLD, but that FIB-4 remains a first-line test for advanced fibrosis.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Wiggers, ThomasNordic Bioscience, Herlev, Denmark,Nord Biosci, Herlev, Denmark. (författare)
  • Nasr, PatrikLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken(Swepub:liu)patna19 (författare)
  • Vessby, Johan,1972-Uppsala universitet,Gastroenterologi/hepatologi,Uppsala Univ, Sweden(Swepub:uu)johve343 (författare)
  • Kechagias, StergiosLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken(Swepub:liu)steke00 (författare)
  • Nyhlin, Nils,1971-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Gastroenterology,Örebro Univ, Fac Med & Hlth, Dept Gastroenterol, Örebro, Sweden.(Swepub:oru)nnn (författare)
  • Marschall, Hanns-UlrichSahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Gothenburg, Sweden. (författare)
  • Borssén, Åsa DanielssonUmeå University Hospital, Umeå, Sweden,Umeå Univ Hosp, Umeå, Sweden. (författare)
  • Strandberg, RickardKarolinska Institutet (författare)
  • Karsdal, MortenNordic Bioscience, Herlev, Denmark,Nord Biosci, Herlev, Denmark. (författare)
  • Leeming, Diana JulieNordic Bioscience, Herlev, Denmark,Nord Biosci, Herlev, Denmark. (författare)
  • Ekstedt, MattiasLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken(Swepub:liu)matek92 (författare)
  • Hagström, HannesDivision of Hepatology, Department of Upper GI, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden,Karolinska Univ Hosp, Dept Upper GI, Div Hepatol, Stockholm, Sweden.;Karolinska Inst, Dept Med, Stockholm, Sweden. (författare)
  • Division of Hepatology, Department of Upper GI, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, SwedenKarolinska Univ Hosp, Dept Upper GI, Div Hepatol, Stockholm, Sweden.;Karolinska Inst, Dept Med, Stockholm, Sweden. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Internal Medicine: Wiley-Blackwell296:2, s. 177-1860954-68201365-2796

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