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Expression of influ...
Expression of influenza A virus glycan receptor candidates in mallard, chicken, and tufted duck
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- Nilsson, Jonas, 1970 (författare)
- Gothenburg University,Göteborgs universitet,Core Facilities, Proteomics,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Core Facilities, Proteomics,Department of Laboratory Medicine
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Eriksson, Per (författare)
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Naguib, Mahmoud M. (författare)
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Jax, Elinor (författare)
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- Sihlbom, Carina, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Core Facilities, Proteomics,Core Facilities, Proteomics
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- Olsson, Britt-Marie (författare)
- Gothenburg University,Göteborgs universitet,Core Facilities, Proteomics,Core Facilities, Proteomics
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Lundkvist, Ake (författare)
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Olsen, Bjorn (författare)
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Jarhult, Josef D. (författare)
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- Larson, Göran, 1953 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
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Ellstrom, Patrik (författare)
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: GLYCOBIOLOGY. - 0959-6658 .- 1460-2423. ; 34:3
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Influenza A virus (IAV) pandemics result from interspecies transmission events within the avian reservoir and further into mammals including humans. Receptor incompatibility due to differently expressed glycan structures between species has been suggested to limit zoonotic IAV transmission from the wild bird reservoir as well as between different bird species. Using glycoproteomics, we have studied the repertoires of expressed glycan structures with focus on putative sialic acid-containing glycan receptors for IAV in mallard, chicken and tufted duck; three bird species with different roles in the zoonotic ecology of IAV. The methodology used pinpoints specific glycan structures to specific glycosylation sites of identified glycoproteins and was also used to successfully discriminate alpha 2-3- from alpha 2-6-linked terminal sialic acids by careful analysis of oxonium ions released from glycopeptides in tandem MS/MS (MS2), and MS/MS/MS (MS3). Our analysis clearly demonstrated that all three bird species can produce complex N-glycans including alpha 2-3-linked sialyl Lewis structures, as well as both N- and O- glycans terminated with both alpha 2-3- and alpha 2-6-linked Neu5Ac. We also found the recently identified putative IAV receptor structures, Man-6P N-glycopeptides, in all tissues of the three bird species. Furthermore, we found many similarities in the repertoires of expressed receptors both between the bird species investigated and to previously published data from pigs and humans. Our findings of sialylated glycan structures, previously anticipated to be mammalian specific, in all three bird species may have major implications for our understanding of the role of receptor incompatibility in interspecies transmission of IAV.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- birds
- glycoproteomics
- influenza virus
- interspecies transmission
- sialic acid receptor
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- ref (ämneskategori)
- art (ämneskategori)
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Nilsson, Jonas, ...
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Eriksson, Per
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Naguib, Mahmoud ...
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Jax, Elinor
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Sihlbom, Carina, ...
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Olsson, Britt-Ma ...
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Lundkvist, Ake
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Olsen, Bjorn
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Jarhult, Josef D ...
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Larson, Göran, 1 ...
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Ellstrom, Patrik
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