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The use of antibiot...
The use of antibiotic-loaded bone cement and systemic antibiotic prophylactic use in 2,971,357 primary total knee arthroplasties from 2010 to 2020: an international register-based observational study among countries in Africa, Europe, North America, and Oceania
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- Leta, Tesfaye H. (author)
- Haukeland University Hospital,VID Specialized University,Kaiser Permanente,Weill Cornell Medical College
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- Fenstad, Anne Marie (author)
- Haukeland University Hospital
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- Lygre, Stein Håkon L. (author)
- Haukeland University Hospital
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- Lie, Stein Atle (author)
- University of Bergen,Haukeland University Hospital
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- Lindberg-Larsen, Martin (author)
- Danish Knee Arthroplasty Register,Odense University Hospital
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- Pedersen, Alma B. (author)
- Aarhus University Hospital,Danish Knee Arthroplasty Register
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- W-Dahl, Annette (author)
- Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Swedish Arthroplasty Register, Gothenburg
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- Rolfson, Ola, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för ortopedi,Institute of Clinical Sciences, Department of Orthopaedics,Swedish Arthroplasty Register, Gothenburg,Sahlgrenska Academy
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- Bülow, Erik (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för ortopedi,Institute of Clinical Sciences, Department of Orthopaedics,The County of Västra Götaland,Sahlgrenska Academy,Dutch Arthroplasty Register
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- Ashforth, James A. (author)
- JointCare
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- VAN STEENBERGEN, Liza N. (author)
- The Germany Arthroplasty Registry,Romanian Arthroplasty Registry,University of Bucharest,National Joint Registry
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- Nelissen, Rob G.H.H. (author)
- Leiden University Medical Centre,Dutch Arthroplasty Register,Haukeland University Hospital
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- Harries, Dylan (author)
- South Australian Health and Medical Research Institute
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- DE STEIGER, Richard (author)
- Australian Orthopaedic Association National Joint Replacement Registry,University of Wisconsin-Madison,University of Bucharest,Romanian Arthroplasty Registry
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- Lutro, Olav (author)
- Stavanger University Hospital
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- Hakulinen, Emmi (author)
- Finnish National Institute for Health and Welfare
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- Mäkelä, Keijo (author)
- The Finnish Arthroplasty Register,Turku University Hospital
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- Willis, Jinny (author)
- New Zealand Joint Registry
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- Wyatt, Michael (author)
- New Zealand Joint Registry
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- Frampton, Chris (author)
- New Zealand Joint Registry
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Grimberg, Alexander (author)
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Steinbrück, Arnd (author)
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- Wu, Yinan (author)
- The Germany Arthroplasty Registry
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- Armaroli, Cristiana (author)
- Trento Provincial Authority for Health Services
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- Molinari, Marco (author)
- Trento Provincial Authority for Health Services
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- Picus, Roberto (author)
- Arthroplasty Register of Bolzano (PABZ)
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- Mullen, Kyle (author)
- American Joint Replacement Registry
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Illgen, Richard (author)
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- Stoica, Ioan C. (author)
- Carol Davila University of Medicine and Pharmacy
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Vorovenci, Andreea E. (author)
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Dragomirescu, Dan (author)
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- Dale, Håvard (author)
- Haukeland University Hospital
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- Brand, Christian (author)
- University of Bern
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- Christen, Bernhard (author)
- Articon,Swiss National Hip and Knee Joint Registry
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- Shapiro, Joanne (author)
- National Joint Registry
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- Wilkinson, J. Mark (author)
- University of Sheffield
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Armstrong, Richard (author)
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- Wooster, Kate (author)
- National Joint Registry
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Hallan, Geir (author)
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- Gjertsen, Jan Erik (author)
- Haukeland University Hospital
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- Chang, Richard N. (author)
- Kaiser Permanente
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- Prentice, Heather A. (author)
- Kaiser Permanente
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- Paxton, Elizabeth W. (author)
- Kaiser Permanente
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- Furnes, Ove (author)
- Haukeland University Hospital
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Acta Orthopaedica. - 1745-3674 .- 1745-3682. ; 94, s. 416-425
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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Abstract
Subject headings
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- Background and purpose — Antibiotic-loaded bone cement (ALBC) and systemic antibiotic prophylaxis (SAP) have been used to reduce periprosthetic joint infection (PJI) rates. We investigated the use of ALBC and SAP in primary total knee arthroplasty (TKA). Patients and methods — This observational study is based on 2,971,357 primary TKAs reported in 2010–2020 to national/regional joint arthroplasty registries in Australia, Den-mark, Finland, Germany, Italy, the Netherlands, New Zealand, Norway, Romania, South Africa, Sweden, Switzerland, the UK, and the USA. Aggregate-level data on trends and types of bone cement, antibiotic agents, and doses and duration of SAP used was extracted from participating registries. Results — ALBC was used in 77% of the TKAs with variation ranging from 100% in Norway to 31% in the USA. Palacos R+G was the most common (62%) ALBC type used. The primary antibiotic used in ALBC was gentamicin (94%). Use of ALBC in combination with SAP was common practice (77%). Cefazolin was the most common (32%) SAP agent. The doses and duration of SAP used varied from one single preoperative dosage as standard practice in Bolzano, Italy (98%) to 1-day 4 doses in Norway (83% of the 40,709 TKAs reported to the Norwegian arthroplasty register). Conclusion — The proportion of ALBC usage in primary TKA varies internationally, with gentamicin being the most common antibiotic. ALBC in combination with SAP was common practice, with cefazolin the most common SAP agent. The type of ALBC and type, dose, and duration of SAP varied among participating countries.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Leta, Tesfaye H.
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Fenstad, Anne Ma ...
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Lygre, Stein Håk ...
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Lie, Stein Atle
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Lindberg-Larsen, ...
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Pedersen, Alma B ...
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show more...
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W-Dahl, Annette
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Rolfson, Ola, 19 ...
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Bülow, Erik
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Ashforth, James ...
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VAN STEENBERGEN, ...
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Nelissen, Rob G. ...
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Harries, Dylan
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DE STEIGER, Rich ...
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Lutro, Olav
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Hakulinen, Emmi
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Mäkelä, Keijo
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Willis, Jinny
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Wyatt, Michael
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Frampton, Chris
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Grimberg, Alexan ...
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Steinbrück, Arnd
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Wu, Yinan
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Armaroli, Cristi ...
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Molinari, Marco
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Picus, Roberto
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Mullen, Kyle
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Illgen, Richard
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Stoica, Ioan C.
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Vorovenci, Andre ...
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Dragomirescu, Da ...
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Dale, Håvard
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Brand, Christian
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Christen, Bernha ...
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Shapiro, Joanne
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Wilkinson, J. Ma ...
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Armstrong, Richa ...
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Wooster, Kate
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Hallan, Geir
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Gjertsen, Jan Er ...
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Chang, Richard N ...
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Prentice, Heathe ...
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Paxton, Elizabet ...
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Furnes, Ove
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Orthopaedics
- Articles in the publication
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Acta Orthopaedic ...
- By the university
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University of Gothenburg
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Lund University