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Mortality in patien...
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Allosso, Francesca
(author)
Mortality in patients with adrenal insufficiency: a protocol for a systematic review and meta-analysis.
- Article/chapterEnglish2024
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LIBRIS-ID:oai:gup.ub.gu.se/334487
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https://gup.ub.gu.se/publication/334487URI
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https://doi.org/10.1136/bmjopen-2023-076582DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Adrenal insufficiency (AI) is a rare disorder characterised by an impaired secretion of glucocorticoids from the adrenal glands. Treatment strategies for AI have developed over time with reduced glucocorticoid replacement doses and improved circadian exposure regimens, but whether this has resulted in better survival is unknown. The main purpose of this systematic review is to gather and synthesise available evidence on long-term mortality in patients with AI. The secondary aim is to study causes of death, with focus on cardiovascular and infectious diseases, in AI patients.Studies published from the inception of respective databases (Medline, Embase, Cochrane and Web of Science) until the end of May 2023 will be systematically synthetised. Observational studies with a reference population will be included, and their quality will be assessed using the Newcastle-Ottawa scale. Data collected will be narratively integrated and a meta-analysis will be performed to pool data from studies considered homogeneous. The systematic review will be reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. This will be the first systematic review assessing mortality and causes of death in AI patients. The findings of this systematic review will be of value for both patients and healthcare providers.This systematic review does not require ethical approval or informed consent because it will be based on previously published data only and does not implicate any direct contact with individual patients. The research results will be presented at scientific conferences and submitted for publication in an internationally recognised peer-reviewed scientific journal.CRD42023416253.
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Dalakas, Konstantinos,1984Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xdalko
(author)
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Bergthorsdottir, Ragnhildur,1971Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xberag
(author)
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Chantzichristos, Dimitrios,1976Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xchadi
(author)
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Hessman, Eva,1961Gothenburg University,Göteborgs universitet,Göteborgs universitetsbibliotek, Biomedicinska biblioteken,Gothenburg University Library, Biomedical Libraries(Swepub:gu)xhesev
(author)
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Nwaru, Bright I,1978Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Krefting Research Centre(Swepub:gu)xnwabr
(author)
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Bobbio, EmanueleGothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine(Swepub:gu)xbobem
(author)
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Pasquali, Daniela
(author)
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Johannsson, Gudmundur,1960Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xjgudn
(author)
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Esposito, DanielaGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xespda
(author)
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Göteborgs universitetInstitutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition
(creator_code:org_t)
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