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Prognostic value of...
Prognostic value of gut microbe-generated metabolite phenylacetylglutamine in patients with heart failure
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Tang, W. H. Wilson (författare)
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Nemet, Ina (författare)
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Li, Xinmin S. (författare)
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Wu, Yuping (författare)
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Haghikia, Arash (författare)
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Witkowski, Marco (författare)
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Koeth, Robert A. (författare)
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Demuth, Ilja (författare)
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Koenig, Maximilian (författare)
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Steinhagen-Thiessen, Elisabeth (författare)
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- Bäckhed, Fredrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Fischbach, Michael A. (författare)
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Deb, Arjun (författare)
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Landmesser, Ulf (författare)
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Hazen, Stanley L. (författare)
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: EUROPEAN JOURNAL OF HEART FAILURE. - 1388-9842 .- 1879-0844.
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- AimPhenylacetylglutamine (PAGln) is a phenylalanine-derived metabolite produced by gut microbiota with mechanistic links to heart failure (HF)-relevant phenotypes. We sought to investigate the prognostic value of PAGln in patients with stable HF.Methods and resultsFasting plasma PAGln levels were measured by stable-isotope-dilution liquid chromatography-tandem mass spectrometry (LC-MS/MS) in patients with stable HF from two large cohorts. All-cause mortality was assessed at 5-year follow-up in the Cleveland cohort, and HF, hospitalization, or mortality were assessed at 3-year follow-up in the Berlin cohort. Within the Cleveland cohort, median PAGln levels were 4.2 (interquartile range [IQR] 2.4-6.9) mu M. Highest quartile of PAGln was associated with 3.09-fold increased mortality risk compared to lowest quartile. Following adjustments for traditional risk factors, as well as race, estimated glomerular filtration rate, amino-terminal pro-B-type natriuretic peptide, high-sensitivity C-reactive protein, left ventricular ejection fraction, ischaemic aetiology, and HF drug treatment, elevated PAGln levels remained predictive of 5-year mortality in quartile comparisons (adjusted hazard ratio [HR] [95% confidence interval, CI] for Q4 vs Q1: 1.64 [1.07-2.53]). In the Berlin cohort, a similar distribution of PAGln levels was observed (median 3.2 [IQR 2.0-4.8] mu M), and PAGln levels were associated with a 1.92-fold increase in 3-year HF hospitalization or all-cause mortality risk (adjusted HR [95% CI] for Q4 vs Q1: 1.92 [1.02-3.61]). Prognostic value of PAGln appears to be independent of trimethylamine N-oxide levels.ConclusionHigh levels of PAGln are associated with adverse outcomes independent of traditional cardiac risk factors and cardio-renal risk markers.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Phenylacetylglutamine
- Heart failure
- Microbiome
- Trimethylamine N-oxide
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Tang, W. H. Wils ...
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Nemet, Ina
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Li, Xinmin S.
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Wu, Yuping
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Haghikia, Arash
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Witkowski, Marco
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visa fler...
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Koeth, Robert A.
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Demuth, Ilja
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Koenig, Maximili ...
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Steinhagen-Thies ...
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Bäckhed, Fredrik ...
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Fischbach, Micha ...
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Deb, Arjun
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Landmesser, Ulf
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Hazen, Stanley L ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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EUROPEAN JOURNAL ...
- Av lärosätet
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Göteborgs universitet