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Initial surveillanc...
Initial surveillance in men with marker negative clinical stage IIA non-seminomatous germ cell tumours
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- Gerdtsson, Axel (författare)
- Karolinska Institute,Skåne University Hospital
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- Negaard, Helene F. S. (författare)
- Department of Oncology, Oslo University Hospital, Oslo, Norway
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- Almas, Bjarte (författare)
- Department of Urology, Haukeland University Hospital, Bergen, Norway
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- Grenabo Bergdahl, Anna (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology,Department of Urology, Institute of Clinical Science, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Urology, Region Västra Götaland, Sahlgrenska University Hospital, Gothenborg, Sweden
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- Cohn-Cedermark, Gabriella (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska University Hospital
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- Glimelius, Ingrid (författare)
- Uppsala University,Karolinska Institutet
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- Halvorsen, Dag (författare)
- Department of Urology, St. Olavs University Hospital, Trondheim, Norway
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- Haugnes, Hege Sagstuen (författare)
- Department of Oncology, University Hospital of North Norway, Tromsø, Norway; Department of Clinical Medicine, UIT- The Arctic University of Norway, Tromsø, Norway
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- Hedlund, Annika (författare)
- Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden
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- Hellström, Martin (författare)
- Umeå University,Umeå universitet,Onkologi
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- Holmberg, Goran (författare)
- Department of Urology, Region Västra Götaland, Sahlgrenska University Hospital, Gothenborg, Sweden
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- Karlsdottir, Asa (författare)
- Department of Oncology, Haukeland University Hospital, Bergen, Norway
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- Kjellman, Anders (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska University Hospital
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- Larsen, Signe Melsen (författare)
- Department of Urology, Oslo University Hospital, Oslo, Norway
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- Thor, Anna (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska University Hospital
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- Wahlqvist, Rolf (författare)
- Department of Urology, Oslo University Hospital, Oslo, Norway
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- Ståhl, Olof (författare)
- Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Tandstad, Torgrim (författare)
- The Cancer Clinic, St. Olavs University Hospital, Trondheim, Norway; Department of Clinical and Molecular Medicine, The Norwegian University of Science and Technology, Trondheim, Norway
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(creator_code:org_t)
- John Wiley & Sons, 2024
- 2024
- Engelska.
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Ingår i: BJU INTERNATIONAL. - : John Wiley & Sons. - 1464-4096 .- 1464-410X. ; 133:6, s. 717-724
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Objectives To assess whether extended surveillance with repeated computed tomography (CT) scans for patients with clinical stage IIA (CS IIA; <2 cm abdominal node involvement) and negative markers (Mk-) non-seminomatous germ cell tumours (NSGCTs) can identify those with true CS I. To assess the rate of benign lymph nodes, teratoma, and viable cancer in retroperitoneal lymph node dissection (RPLND) histopathology for patients with CS IIA Mk- NSGCT. Patients and methods Observational prospective population-based study of patients diagnosed 2008-2019 with CS IIA Mk- NSGCT in the Swedish and Norwegian Testicular Cancer Group (SWENOTECA) registry. Patients were managed with surveillance, with CT scans, and tumour markers every sixth week for a maximum of 18 weeks. Patients with radiological regression were treated as CS I, if progression with chemotherapy, and remaining CS IIA Mk- disease with RPLND. The end-point was the number and percentage of patients down-staged to CS I on surveillance and rate of RPLND histopathology presented as benign, teratoma, or viable cancer. Results Overall, 126 patients with CS IIA Mk- NSGCT were included but 41 received therapy upfront. After surveillance for a median (range) of 6 (6-18) weeks, 23/85 (27%) patients were in true CS I and four (5%) progressed. Of the remaining 58 patients with lasting CS IIA Mk- NSGCT, 16 received chemotherapy and 42 underwent RPLND. The RPLND histopathology revealed benign lymph nodes in 11 (26%), teratoma in two (6%), and viable cancer in 29 (70%) patients. Conclusions Surveillance with repeated CT scans can identify patients in true CS I, thus avoiding overtreatment. The RPLND histopathology in patients with CS IIA Mk- NSGCT had a high rate of cancer and a low rate of teratoma.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- chemotherapy
- germ cell tumour
- non-seminoma
- retroperitoneal lymph node dissection
- testicular cancer
- chemotherapy
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Gerdtsson, Axel
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Negaard, Helene ...
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Almas, Bjarte
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Grenabo Bergdahl ...
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Cohn-Cedermark, ...
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Glimelius, Ingri ...
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visa fler...
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Halvorsen, Dag
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Haugnes, Hege Sa ...
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Hedlund, Annika
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Hellström, Marti ...
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Holmberg, Goran
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Karlsdottir, Asa
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Kjellman, Anders
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Larsen, Signe Me ...
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Thor, Anna
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Wahlqvist, Rolf
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Ståhl, Olof
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Tandstad, Torgri ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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BJU INTERNATIONA ...
- Av lärosätet
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Göteborgs universitet
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Umeå universitet
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Karolinska Institutet
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Lunds universitet