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The interplay betwe...
The interplay between dietary fatty acids and gut microbiota influences host metabolism and hepatic steatosis
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- Schöler, Marc, 1987 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Ellero-Simatos, Sandrine (author)
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Birkner, Till (author)
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Mayneris-Perxachs, Jordi (author)
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- Olsson, Lisa M., 1984 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Brolin, Harald, 1992 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Loeber, Ulrike (author)
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- Kraft, Jamie D. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Polizzi, Arnaud (author)
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Marti-Navas, Marian (author)
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Puig, Josep (author)
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Moschetta, Antonio (author)
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Montagner, Alexandra (author)
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Gourdy, Pierre (author)
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Heymes, Christophe (author)
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Guillou, Herve (author)
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- Tremaroli, Valentina, 1978 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Fernandez-Real, Jose Manuel (author)
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Forslund, Sofia K. (author)
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Burcelin, Remy (author)
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- Caesar, Robert, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: NATURE COMMUNICATIONS. - 2041-1723. ; 14:1
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Dietary lipids can affect metabolic health through gut microbiota-mediated mechanisms, but the influence of lipid-microbiota interaction on liver steatosis is largely unknown. We investigate the impact of dietary lipids on human gut microbiota composition and the effects of microbiota-lipid interactions on steatosis in male mice. In humans, low intake of saturated fatty acids (SFA) is associated with increased microbial diversity independent of fiber intake. In mice, poorly absorbed dietary long-chain SFA, particularly stearic acid, induce a shift in bile acid profile and improved metabolism and steatosis. These benefits are dependent on the gut microbiota, as they are transmitted by microbial transfer. Diets enriched in polyunsaturated fatty acids are protective against steatosis but have minor influence on the microbiota. In summary, we find that diets enriched in poorly absorbed long-chain SFA modulate gut microbiota profiles independent of fiber intake, and this interaction is relevant to improve metabolism and decrease liver steatosis. Here, Schoeler et al. investigate how interaction between dietary lipids and the gut microbiota affect hepatic steatosis and host metabolism, showing that dietary lipids impact the gut microbiota composition independent on fiber intake in humans and mice.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Schöler, Marc, 1 ...
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Ellero-Simatos, ...
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Birkner, Till
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Mayneris-Perxach ...
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Olsson, Lisa M., ...
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Brolin, Harald, ...
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show more...
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Loeber, Ulrike
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Kraft, Jamie D.
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Polizzi, Arnaud
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Marti-Navas, Mar ...
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Puig, Josep
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Moschetta, Anton ...
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Montagner, Alexa ...
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Gourdy, Pierre
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Heymes, Christop ...
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Guillou, Herve
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Tremaroli, Valen ...
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Fernandez-Real, ...
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Forslund, Sofia ...
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Burcelin, Remy
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Caesar, Robert, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
- Articles in the publication
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NATURE COMMUNICA ...
- By the university
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University of Gothenburg