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  • Lannering, KatarinaGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Region Västra Götaland, Children’s Heart Center, Queen Silvia Children’s Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Pediatrics, Institution of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden (author)

Screening for Critical Congenital Heart Defects in Sweden

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • American Academy of Pediatrics (AAP),2023

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/335560
  • https://gup.ub.gu.se/publication/335560URI
  • https://doi.org/10.1542/peds.2023-061949DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-217885URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:237732389URI
  • https://lup.lub.lu.se/record/89363a8e-08ab-4866-9dc3-f68aedb44119URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:154956545URI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • OBJECTIVES Early diagnosis of critical congenital heart defects (CCHD) improves survival. We evaluated the relative contributions of prenatal ultrasound, neonatal pulse oximetry screening (POS), and neonatal physical examination (NPE) to the early detection (before discharge) of CCHD in the context of increasing prenatal detection, and POS being a national standard since 2013.METHODS Retrospective, nationwide population-based study. All full-term live-born infants with CCHD in Sweden between 2014 and 2019 were included. CCHD was defined as a congenital heart defect requiring surgery or catheter-based intervention or resulting in death within 28 days of birth.RESULTS Of 630 infants, 89% were diagnosed before discharge or death, 42% prenatally, 11% from early symptoms, 23% by POS, and 14% from NPE after a negative POS. Four (0.6%) died undiagnosed before discharge and 64/630 (10%) were discharged undiagnosed, with 24/64 being readmitted with circulatory failure and causing 1 preoperative death. Coarctation was the most prevalent CCHD (N = 184), 25% of whom were detected prenatally (12% by POS and 29% by NPE). Two died undiagnosed before discharge and 30% were discharged undiagnosed. Transposition was the second most common defect (N = 150) and 43% were detected prenatally (33% by POS, 1 by NPE) and 2 died undiagnosed before POS. None was discharged undiagnosed.CONCLUSIONS POS and NPE remain important for the early detection of CCHD complementing prenatal ultrasound screening. Nevertheless, 1 in 10 with CCHD leaves the hospital without a diagnosis, with coarctation being the predominant lesion. Future research on CCHD screening should have a particular focus on this cardiac defect.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Kazamia, KalliopiKarolinska Institute,Karolinska University Hospital (author)
  • Bergman, GunnarKarolinska Institute,Karolinska Institutet,Karolinska University Hospital (author)
  • Östman-Smith, Ingegerd,1947Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Department of Pediatrics, Institution of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden(Swepub:gu)xostin (author)
  • Liuba, PetruLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Barnkardiologi,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Children cardiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)pedi-pli (author)
  • Alenius Dahlqvist, Jenny,1972-Umeå University,Umeå universitet,Pediatrik(Swepub:umu)jeah0012 (author)
  • Elfvin, Anders,1971Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Department of Pediatrics, Institution of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden; Region Västra Götaland, Department of Pediatrics, Queen Silvia Children’s Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden(Swepub:gu)xelfan (author)
  • Mellander, Mats,1947Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Region Västra Götaland, Children’s Heart Center, Queen Silvia Children’s Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Pediatrics, Institution of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden(Swepub:gu)xmemat (author)
  • Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för pediatrik (creator_code:org_t)

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  • In:PEDIATRICS: American Academy of Pediatrics (AAP)152:40031-40051098-4275

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