Search: WFRF:(Mehdipoor Ghazaleh)
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Hypertension, Micro...
Hypertension, Microvascular Obstruction and Infarct Size in Patients with STEMI Undergoing PCI: Pooled Analysis from 7 Cardiac Magnetic Resonance Imaging Studies.
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Mehdipoor, Ghazaleh (author)
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- Redfors, Björn (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Chen, Shmuel (author)
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Gkargkoulas, Fotios (author)
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Zhang, Zixuan (author)
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Patel, Manesh R (author)
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Granger, Christopher B (author)
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Ohman, E Magnus (author)
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Maehara, Akiko (author)
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Eitel, Ingo (author)
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Ben-Yehuda, Ori (author)
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de Waha-Thiele, Suzanne (author)
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Thiele, Holger (author)
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Stone, Gregg W (author)
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: American heart journal. - 1097-6744.
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Mortality after ST-segment elevation myocardial infarction (STEMI) is increased in patients with hypertension. The mechanisms underlying this association are uncertain. We sought to investigate whether patients with STEMI and prior hypertension have greater microvascular obstruction (MVO) and infarct size (IS) compared with those without hypertension.We pooled individual patient data from 7 randomized trials of patients with STEMI undergoing primary percutaneous coronary intervention (PCI) in whom cardiac magnetic resonance imaging was performed within 1 month after reperfusion. The associations between hypertension and MVO, IS, and mortality were assessed in multivariable adjusted models.Among 2174 patients (61.3±12.6 years, 76% male), 1196 (55.0%) had hypertension. Patients with hypertension were older, more frequently diabetic and had more extensive coronary artery disease than those without hypertension. MVO and IS measured as percent LV mass were not significantly different in patients with and without hypertension (adjusted differences 0.1, 95% CI -0.3 to 0.6, p=0.61 and -0.2, 95% CI -1.5 to 1.2, p=0.80, respectively). Hypertension was associated with a higher unadjusted risk of 1-year death (hazard ratio [HR] 2.28, 95% CI 1.44-3.60, p<0.001), but was not independently associated with higher mortality after multivariable adjustment (adjusted HR 1.04, 95% CI 0.60-1.79, p=0.90).In this large-scale individual patient data pooled analysis, hypertension was not associated with larger IS or MVO after primary PCI for STEMI.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Mehdipoor, Ghaza ...
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Redfors, Björn
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Chen, Shmuel
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Gkargkoulas, Fot ...
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Zhang, Zixuan
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Patel, Manesh R
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show more...
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Granger, Christo ...
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Ohman, E Magnus
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Maehara, Akiko
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Eitel, Ingo
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Ben-Yehuda, Ori
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de Waha-Thiele, ...
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Thiele, Holger
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Stone, Gregg W
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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American heart j ...
- By the university
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University of Gothenburg