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  • van Akkooi, Alexander C. J. (author)

Neoadjuvant Systemic Therapy (NAST) in Patients with Melanoma: Surgical Considerations by the International Neoadjuvant Melanoma Consortium (INMC)

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-01-28
  • Springer Science and Business Media LLC,2022

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/335693
  • https://gup.ub.gu.se/publication/335693URI
  • https://doi.org/10.1245/s10434-021-11236-yDOI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Exciting advances in melanoma systemic therapies have presented the opportunity for surgical oncologists and their multidisciplinary colleagues to test the neoadjuvant systemic treatment approach in high-risk, resectable metastatic melanomas. Here we describe the state of the science of neoadjuvant systemic therapy (NAST) for melanoma, focusing on the surgical aspects and the key role of the surgical oncologist in this treatment paradigm. This paper summarizes the past decade of developments in melanoma treatment and the current evidence for NAST in stage III melanoma specifically. Issues of surgical relevance are discussed, including the risk of progression on NAST prior to surgery. Technical aspects, such as the definition of resectability for melanoma and the extent and scope of routine surgery are presented. Other important issues, such as the utility of radiographic response evaluation and method of pathologic response evaluation, are addressed. Surgical complications and perioperative management of NAST related adverse events are considered. The International Neoadjuvant Melanoma Consortium has the goal of harmonizing NAST trials in melanoma to facilitate rapid advances with new approaches, and facilitating the comparison of results across trials evaluating different treatment regimens. Our ultimate goals are to provide definitive proof of the safety and efficacy of NAST in melanoma, sufficient for NAST to become an acceptable standard of care, and to leverage this platform to allow more personalized, biomarker-driven, tailored approaches to subsequent treatment and surveillance.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Hieken, Tina J. (author)
  • Burton, Elizabeth M. (author)
  • Ariyan, Charlotte (author)
  • Ascierto, Paolo A. (author)
  • Asero, Salvatore V. M. A. (author)
  • Blank, Christian U. (author)
  • Block, Matthew S. (author)
  • Boland, Genevieve M. (author)
  • Caraco, Corrado (author)
  • Chng, Sydney (author)
  • Davidson, B. Scott (author)
  • Duprat Neto, Joao Pedreira (author)
  • Faries, Mark B. (author)
  • Gershenwald, Jeffrey E. (author)
  • Grunhagen, Dirk J. (author)
  • Gyorki, David E. (author)
  • Han, Dale (author)
  • Hayes, Andrew J. (author)
  • van Houdt, Winan J. (author)
  • Karakousis, George C. (author)
  • Klop, Willem M. C. (author)
  • Long, Georgina (author)
  • Lowe, Michael C. (author)
  • Menzies, Alexander M. (author)
  • Olofsson Bagge, Roger,1978Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery(Swepub:gu)xoloro (author)
  • Pennington, Thomas E. (author)
  • Rutkowski, Piotr (author)
  • Saw, Robyn P. M. (author)
  • Scolyer, Richard A. (author)
  • Shannon, Kerwin F. (author)
  • Sondak, Vernon K. (author)
  • Tawbi, Hussein (author)
  • Testori, Alessandro A. E. (author)
  • Tetzlaff, Mike T. (author)
  • Thompson, John F. (author)
  • Zager, Jonathan S. (author)
  • Zuur, Charlotte L. (author)
  • Wargo, Jennifer A. (author)
  • Spillane, Andrew J. (author)
  • Ross, Merrick (author)
  • Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för kirurgi (creator_code:org_t)

Related titles

  • In:ANNALS OF SURGICAL ONCOLOGY: Springer Science and Business Media LLC29:6, s. 3694-37081068-92651534-4681

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