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Sökning: WFRF:(Torell Agnes) > Low CD4+T cell coun...

  • Torell, Agnes,1993Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Sahlgrenska Academy,Univ Gothenburg, Inst Med, Sahlgrenska Acad, Dept Rheumatol & Inflammat Res, Guldhedsgatan 10A, S-40530 Gothenburg, Sweden. (författare)

Low CD4+T cell count is related to specific anti-nuclear antibodies, IFNα protein positivity and disease activity in systemic lupus erythematosus pregnancy.

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • BioMed Central (BMC),2024

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/335721
  • https://gup.ub.gu.se/publication/335721URI
  • https://doi.org/10.1186/s13075-024-03301-0DOI
  • https://lup.lub.lu.se/record/3df9b9f9-4c10-4cda-a3d0-47aea0455e70URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-525920URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:155249696URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-202281URI

Kompletterande språkuppgifter

  • Språk:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|University of Gothenburg; Swedish Research Council; Swedish state; ALF-agreement; foundations of The King Gustaf V's 80th Birthday found; Swedish Rheumatism Association; Gothenburg Society of Medicine; Foundation of Ulla; Foundation of Roland; Gustafsson; Nanna Svartz; Rune; Ulla Amloev; Hjalmar Svensson; IngaBritt; Arne Lundberg; Ingegerd Johansson; Emil and Wera Cornell; Swedish Society of Medicine
  • Lymphopenia, autoantibodies and activation of the type I interferon (IFN) system are common features in systemic lupus erythematosus (SLE). We speculate whether lymphocyte subset counts are affected by pregnancy and if they relate to autoantibody profiles and/or IFNα protein in SLE pregnancy.Repeated blood samples were collected during pregnancy from 80 women with SLE and 51 healthy controls (HC). Late postpartum samples were obtained from 19 of the women with SLE. Counts of CD4+and CD8+T cells, B cells and NK cells were measured by flow cytometry. Positivity for anti-nuclear antibodies (ANA) fine specificities (double-stranded DNA [dsDNA], Smith [Sm], ribonucleoprotein [RNP], chromatin, Sjögren's syndrome antigen A [SSA] and B [SSB]) and anti-phospholipid antibodies (cardiolipin [CL] and β2 glycoprotein I [β2GPI]) was assessed with multiplexed bead assay. IFNα protein concentration was quantified with Single molecule array (Simoa) immune assay. Clinical data were retrieved from medical records.Women with SLE had lower counts of all lymphocyte subsets compared to HC throughout pregnancy, but counts did not differ during pregnancy compared to postpartum. Principal component analysis revealed that low lymphocyte subset counts differentially related to autoantibody profiles, cluster one (anti-dsDNA/anti-Sm/anti-RNP/anti-Sm/RNP/anti-chromatin), cluster two (anti-SSA/anti-SSB) and cluster three (anti-CL/anti-β2GPI), IFNα protein levels and disease activity. CD4+T cell counts were lower in women positive to all ANA fine specificities in cluster one compared to those who were negative, and B cell numbers were lower in women positive for anti-dsDNA and anti-Sm compared to negative women. Moreover, CD4+T cell and B cell counts were lower in women with moderate/high compared to no/low disease activity, and CD4+T cell count was lower in IFNα protein positive relative to negative women. Finally, CD4+T cell count was unrelated to treatment.Lymphocyte subset counts are lower in SLE compared to healthy pregnancies, which seems to be a feature of the disease per se and not affected by pregnancy. Our results also indicate that low lymphocyte subset counts relate differentially to autoantibody profiles, IFNα protein levels and disease activity, which could be due to divergent disease pathways.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Stockfelt, MaritGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Sahlgrenska Academy,Sahlgrenska University Hospital,Univ Gothenburg, Inst Med, Sahlgrenska Acad, Dept Rheumatol & Inflammat Res, Guldhedsgatan 10A, S-40530 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Rheumatol, Gothenburg, Sweden.(Swepub:gu)xhansx (författare)
  • Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska University Hospital,University of Science and Technology of China,Sahlgrenska Academy,Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Mölndal, Sweden.;Sahlgrens Univ Hosp, Clin Neurochem Lab, Mölndal, Sweden.;Sorbonne Univ, Pitie Salpetriere Hosp, Paris Brain Inst, ICM, Paris, France.;Univ Sci & Technol China, Inst Aging & Brain Disorders, Neurodegenerat Disorder Res Ctr, Div Life Sci & Med, Hefei, Peoples R China.;Univ Sci & Technol China, Inst Aging & Brain Disorders, Dept Neurol, Hefei, Peoples R China.;USTC, Affiliated Hosp 1, Hefei, Peoples R China.(Swepub:lu)med-kbw (författare)
  • Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska Academy,University of Wisconsin-Madison,University College London,Sahlgrenska University Hospital,Hong Kong Center for Neurodegenerative Diseases,Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Mölndal, Sweden.;Sahlgrens Univ Hosp, Clin Neurochem Lab, Mölndal, Sweden.;UCL, Dept Neurodegenerat Dis, Inst Neurol, London, England.;UCL, UK Dementia Res Inst, London, England.;Hong Kong Ctr Neurodegenerat Dis, Clear Water Bay, Hong Kong, Peoples R China.;Univ Wisconsin, Winsconsin Alzheimers Dis Res Ctr, Sch Med & Publ Hlth, Madison, WI USA.(Swepub:lu)med-hiz (författare)
  • Akhter, Tansim,1967-Uppsala universitet,Uppsala University,Klinisk obstetrik,Uppsala Univ, Sweden(Swepub:uu)tanak729 (författare)
  • Leonard, Dag,1975-Uppsala universitet,Uppsala University,Reumatologi,Uppsala Univ, Sweden(Swepub:uu)dagle338 (författare)
  • Rönnblom, LarsUppsala universitet,Uppsala University,Reumatologi,Uppsala Univ, Sweden(Swepub:uu)larsronn (författare)
  • Pihl, SofiaLinköpings universitet,Linköping University,Linköping University Hospital,Linköping Univ Hosp, Dept Obstet & Gynecol, Linköping, Sweden.;Linköping Univ, Dept Biomed & Clin Sci, Div Childrens & Womens Hlth, Linköping, Sweden.,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, Kvinnokliniken US(Swepub:liu)sofkl98 (författare)
  • Saleh, Muna AtallahLinköpings universitet,Linköping University,Linköping Univ, Dept Biomed & Clin Sci, Div Inflammat & Infect, Linköping, Sweden.,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland(Swepub:liu)munsa25 (författare)
  • Sjöwall, ChristopherLinköpings universitet,Linköping University,Linköping Univ, Dept Biomed & Clin Sci, Div Inflammat & Infect, Linköping, Sweden.,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland(Swepub:liu)chrsj93 (författare)
  • Strevens, HelenaSkåne University Hospital,Skane Univ Hosp, Inst Clin Sci, Dept Obstet & Gynecol, Lund, Sweden.(Swepub:lu)gyn-hst (författare)
  • Jönsen, AndreasLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital,Lund Univ, Skane Univ Hosp, Dept Clin Sci Lund, Rheumatol, Lund, Sweden.(Swepub:lu)reum-ajo (författare)
  • Bengtsson, Anders A.Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital,Lund Univ, Skane Univ Hosp, Dept Clin Sci Lund, Rheumatol, Lund, Sweden.(Swepub:lu)reum-abe (författare)
  • Trysberg, EstelleSahlgrenska University Hospital,Sahlgrens Univ Hosp, Rheumatol, Gothenburg, Sweden. (författare)
  • Majczuk Sennström, MariaKarolinska Institutet,Karolinska Univ Hosp, Sweden (författare)
  • Zickert, AgnetaKarolinska Institutet,Karolinska Univ Hosp, Sweden (författare)
  • Svenungsson, ElisabetKarolinska University Hospital,Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Div Rheumatol, Stockholm, Sweden. (författare)
  • Gunnarsson, IvaKarolinska Institutet,Karolinska Univ Hosp, Sweden (författare)
  • Bylund, Johan,1975Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology,Sahlgrenska Academy,Univ Gothenburg, Sahlgrenska Acad, Inst Odontol, Dept Oral Microbiol & Immunol, Gothenburg, Sweden.(Swepub:gu)xbyljo (författare)
  • Jacobsson, Bo,1960Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology,Norwegian Institute of Public Health,Sahlgrenska Academy,Sahlgrenska University Hospital,Sahlgrens Univ Hosp, Dept Obstet & Gynecol, Gothenburg, Sweden.;Univ Gothenburg, Sahlgrenska Acad, Dept Obstet & Gynecol, Gothenburg, Sweden.;Inst Publ Hlth, Dept Genet & Bioinformat, Div Hlth Data & Digitalisat, Oslo, Norway.(Swepub:gu)xjacbo (författare)
  • Rudin, Anna,1961Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Sahlgrenska Academy,Univ Gothenburg, Inst Med, Sahlgrenska Acad, Dept Rheumatol & Inflammat Res, Guldhedsgatan 10A, S-40530 Gothenburg, Sweden.(Swepub:gu)xrudan (författare)
  • Lundell, Anna-Carin,1976Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Sahlgrenska Academy,Univ Gothenburg, Inst Med, Sahlgrenska Acad, Dept Rheumatol & Inflammat Res, Guldhedsgatan 10A, S-40530 Gothenburg, Sweden.(Swepub:gu)xaanni (författare)
  • Göteborgs universitetInstitutionen för medicin, avdelningen för reumatologi och inflammationsforskning (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Arthritis research & therapy: BioMed Central (BMC)26:11478-63621478-6354

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