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Incidence, Predicto...
Incidence, Predictors, and Impact of Hospital Readmission After Revascularization for Left Main Coronary Disease.
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Kosmidou, Ioanna (author)
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Shahim, Bahira (author)
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Dressler, Ovidiu (author)
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- Redfors, Björn (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Morice, Marie-Claude (author)
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Puskas, John D (author)
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Kandzari, David E (author)
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Karmpaliotis, Dimitri (author)
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Brown, W Morris (author)
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Lembo, Nicholas J (author)
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Banning, Adrian P (author)
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Kappetein, Arie Pieter (author)
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Serruys, Patrick W (author)
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Sabik, Joseph F (author)
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Stone, Gregg W (author)
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Journal of the American College of Cardiology. - 1558-3597. ; 83:11, s. 1073-1081
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https://doi.org/10.1...
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Abstract
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- The frequency of and relationship between hospital readmissions and outcomes after revascularization for left main coronary artery disease (LMCAD) are unknown.The purpose of this study was to study the incidence, predictors, and clinical impact of readmissions following percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) for LMCAD.In the EXCEL (XIENCE Versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization) trial, 1,905 patients with LMCAD were randomized to PCI vs CABG. The cumulative incidence of readmissions was analyzed with multivariable Anderson-Gill and joint frailty models to account for recurrent events and the competing risk of death. The impact of readmission on subsequent mortality within 5-year follow-up was determined in a time-adjusted Cox proportional hazards model.Within 5 years, 1,868 readmissions occurred in 851 of 1,882 (45.2%) hospital survivors (2.2 ± 1.9 per patient with readmission[s], range 1-16), approximately one-half for cardiovascular causes and one-half for noncardiovascular causes (927 [49.6%] and 941 [50.4%], respectively). One or more readmissions occurred in 463 of 942 (48.6%) PCI patients vs 388 of 940 (41.8%) CABG patients (P = 0.003). After multivariable adjustment, PCI remained an independent predictor of readmission (adjusted HR: 1.22; 95% CI: 1.10-1.35; P < 0.0001), along with female sex, comorbidities, and the extent of CAD. Readmission was independently associated with subsequent all-cause death, with interaction testing indicating a higher risk after PCI than CABG (adjusted HR: 5.72; 95% CI: 3.42-9.55 vs adjusted HR: 2.72; 95% CI: 1.64-4.88, respectively; Pint = 0.03).In the EXCEL trial, readmissions during 5-year follow-up after revascularization for LMCAD were common and more frequent after PCI than CABG. Readmissions were associated with an increased risk of all-cause death, more so after PCI than with CABG.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Humans
- Female
- Coronary Artery Disease
- epidemiology
- Patient Readmission
- Incidence
- Percutaneous Coronary Intervention
- adverse effects
- Risk Factors
- Treatment Outcome
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kosmidou, Ioanna
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Shahim, Bahira
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Dressler, Ovidiu
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Redfors, Björn
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Morice, Marie-Cl ...
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Puskas, John D
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show more...
-
Kandzari, David ...
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Karmpaliotis, Di ...
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Brown, W Morris
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Lembo, Nicholas ...
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Banning, Adrian ...
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Kappetein, Arie ...
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Serruys, Patrick ...
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Sabik, Joseph F
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Stone, Gregg W
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Journal of the A ...
- By the university
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University of Gothenburg