Effectiveness of secukinumab in radiographic and non-radiographic axial spondyloarthritis : a European routine-care observational study

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Effectiveness of secukinumab in radiographic and non-radiographic axial spondyloarthritis : a European routine-care observational study

Christiansen, Sara Nysom (författare): Copenhagen University Hospital

Rasmussen, Simon Horskjær (författare): Copenhagen University Hospital

Ostergaard, Mikkel (författare): Copenhagen University Hospital,University of Copenhagen

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Pons, Marion (författare): Copenhagen University Hospital

Michelsen, Brigitte (författare): Diakonhjemmet Hospital,Copenhagen University Hospital

Pavelka, Karel (författare): Charles University in Prague

Codreanu, Catalin (författare): Carol Davila University of Medicine and Pharmacy

Ciurea, Adrian (författare): University Hospital of Zurich

Glintborg, Bente (författare): University of Copenhagen,Copenhagen University Hospital

Santos, Maria Jose (författare): Portuguese National Programme for Respiratory Diseases (PNDR),Hospital Garcia de Orta

Sari, Ismail (författare): Dokuz Eylül University

Rotar, Ziga (författare): University Medical Centre Ljubljana,University of Ljubljana

Gudbjornsson, Bjorn (författare): National University Hospital of Iceland,University of Iceland

Macfarlane, Gary J. (författare)

Relas, Heikki (författare): Helsinki University Central Hospital

Iannone, Florenzo (författare): University of Bari Aldo Moro

Laas, Karin (författare)

Wallman, Johan K. (författare): Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund Arthritis Research Group (LARG),Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital

van de Sande, Marleen (författare): University of Amsterdam

Provan, Sella Aarrestad (författare): Inland Norway University of Applied Sciences,Diakonhjemmet Hospital

Castrejon, Isabel (författare): Hospital Gregorio Maranon,Complutense University of Madrid

Zavada, Jakub (författare): Charles University in Prague

Mogosan, Corina (författare): Carol Davila University of Medicine and Pharmacy

Nissen, Michael J. (författare): Geneva University Hospital

Loft, Anne Gitte (författare): Aarhus University Hospital

Barcelos, Anabela (författare): NOVA University Lisbon

Erez, Yesim (författare)

Pirkmajer, Katja Perdan (författare): University of Ljubljana,University Medical Centre Ljubljana

Grondal, Gerdur (författare): National University Hospital of Iceland,University of Iceland

Jones, Gareth T. (författare)

Hokkanen, Anna Mari (författare): University of Helsinki

Chimenti, Maria Sole (författare): University of Rome Tor Vergata

Vorobjov, Sigrid (författare): National Institute for Health Development, Estonia

Giuseppe, Daniela Di (författare): Karolinska Institutet,Karolinska Institute

Kvien, Tore K. (författare): Diakonhjemmet Hospital,University of Oslo

Otero-Varela, Lucia (författare)

van der Horst-Bruinsma, Irene (författare): Radboud University Medical Center

Hetland, Merete Lund (författare): University of Copenhagen,Copenhagen University Hospital

Ørnbjerg, Lykke Midtbøll (författare): Copenhagen University Hospital

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2024
2024
Engelska.
Ingår i: RMD Open. - 2056-5933. ; 10:3

Relaterad länk:: http://dx.doi.org/10... (free); visa fler...; https://lup.lub.lu.s...; https://doi.org/10.1...; http://kipublication...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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Objectives To compare the treatment effectiveness of secukinumab in radiographic (r) versus non-radiographic (nr) axial spondyloarthritis (axSpA) patients treated in routine care across Europe. Methods Prospectively collected data on secukinumab-treated axSpA patients with known radiographic status were pooled from nine countries. Remission rates based on patient-reported outcomes (PROs; Numeric Rating Scale (0–10), for example, pain ≤2/ Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) ≤2 and Ankylosing Spondylitis Disease Activity Score (ASDAS) inactive disease (ID) <1.3 after 6/12/24 months of secukinumab treatment were calculated. Remission and drug retention rates in r-axSpA versus nr-axSpA patients were compared by logistic and Cox regression models (unadjusted/adjusted for age+sex/ adjusted for multiple confounders). Results Overall, 1161 secukinumab-treated patients were included (r-axSpA/nr-axSpA: 922/239). At baseline, r-axSpA patients had longer disease duration and higher C reactive protein, were more often male and HLA-B27 positive and had received fewer prior biological or targeted synthetic disease-modifying antirheumatic drugs compared with nr-axSpA patients, whereas PROs were largely similar. During follow-up, crude PRO remission rates were significantly higher in r-axSpA compared with nr-axSpA patients (6 months: pain≤2: 40%/28%, OR=1.7; BASDAI≤2: 37%/25%, OR=1.8), as were drug retention rates (24 months: 66%/58%, HR 0.73 (ref: r-axSpA)). Proportions of patients achieving ASDAS ID were low for both groups, particularly nr-axSpA (6 months: 11%/8%). However, when adjusting for age+sex, these differences diminished, and after adjusting for multiple confounders, no significant between-group differences remained for either remission or drug retention rates. Conclusion Crude remission/drug retention rates in European secukinumab-treated patients were higher in r-axSpA compared with nr-axSpA patients. In adjusted analyses, secukinumab effectiveness was similar in both groups, suggesting that observed differences were related to factors other than radiographic status.

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Av författaren/redakt...: Christiansen, Sa ...; Rasmussen, Simon ...; Ostergaard, Mikk ...; Pons, Marion; Michelsen, Brigi ...; Pavelka, Karel; visa fler...; Codreanu, Catali ...; Ciurea, Adrian; Glintborg, Bente; Santos, Maria Jo ...; Sari, Ismail; Rotar, Ziga; Gudbjornsson, Bj ...; Macfarlane, Gary ...; Relas, Heikki; Iannone, Florenz ...; Laas, Karin; Wallman, Johan K ...; van de Sande, Ma ...; Provan, Sella Aa ...; Castrejon, Isabe ...; Zavada, Jakub; Mogosan, Corina; Nissen, Michael ...; Loft, Anne Gitte; Barcelos, Anabel ...; Erez, Yesim; Pirkmajer, Katja ...; Grondal, Gerdur; Jones, Gareth T.; Hokkanen, Anna M ...; Chimenti, Maria ...; Vorobjov, Sigrid; Giuseppe, Daniel ...; Kvien, Tore K.; Otero-Varela, Lu ...; van der Horst-Br ...; Hetland, Merete ...; Ørnbjerg, Lykke ...; visa färre...

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Effectiveness of secukinumab in radiographic and non-radiographic axial spondyloarthritis : a European routine-care observational study

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