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Search: WFRF:(Psaty Bruce) > (2020-2024) > A plasma protein-ba...

  • Austin, Thomas R. (author)

A plasma protein-based risk score to predict hip fractures

  • Article/chapterEnglish2024

Publisher, publication year, extent ...

  • 2024

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/339309
  • https://gup.ub.gu.se/publication/339309URI
  • https://doi.org/10.1038/s43587-024-00639-7DOI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • As there are effective treatments to reduce hip fractures, identification of patients at high risk of hip fracture is important to inform efficient intervention strategies. To obtain a new tool for hip fracture prediction, we developed a protein-based risk score in the Cardiovascular Health Study using an aptamer-based proteomic platform. The proteomic risk score predicted incident hip fractures and improved hip fracture discrimination in two Tr & oslash;ndelag Health Study validation cohorts using the same aptamer-based platform. When transferred to an antibody-based proteomic platform in a UK Biobank validation cohort, the proteomic risk score was strongly associated with hip fractures (hazard ratio per s.d. increase, 1.64; 95% confidence interval 1.53-1.77). The proteomic risk score, but not available polygenic risk scores for fractures or bone mineral density, improved the C-index beyond the fracture risk assessment tool (FRAX), which integrates information from clinical risk factors (C-index, FRAX 0.735 versus FRAX + proteomic risk score 0.776). The developed proteomic risk score constitutes a new tool for stratifying patients according to hip fracture risk; however, its improvement in hip fracture discrimination is modest and its clinical utility beyond FRAX with information on femoral neck bone mineral density remains to be determined. The authors developed a proteomic risk score that improved the prediction of hip fractures in three validation cohorts analyzed by two different proteomic platforms. This risk score constitutes a new tool to stratify patients by hip fracture risk.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Nethander, Maria,1980Gothenburg University,Göteborgs universitet,Core Facilities, Bioinformatics,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Core Facilities, Bioinformatics,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xnetma (author)
  • Fink, Howard A. (author)
  • Törnqvist, Anna EGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xbannf (author)
  • Jalal, Diana I. (author)
  • Buzkova, Petra (author)
  • Barzilay, Joshua I. (author)
  • Carbone, Laura (author)
  • Gabrielsen, Maiken E. (author)
  • Grahnemo, LouiseGothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xstlou (author)
  • Lu, Tianyuan (author)
  • Hveem, Kristian (author)
  • Jonasson, Christian (author)
  • Kizer, Jorge R. (author)
  • Langhammer, Arnulf (author)
  • Mukamal, Kenneth J. (author)
  • Gerszten, Robert E. (author)
  • Psaty, Bruce M. (author)
  • Robbins, John A. (author)
  • Sun, Yan V. (author)
  • Skogholt, Anne Heidi (author)
  • Kanis, John A. (author)
  • Johansson, Helena,1981Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xjhell (author)
  • Asvold, Bjorn Olav (author)
  • Valderrabano, Rodrigo J. (author)
  • Zheng, Jie (author)
  • Richards, J. Brent (author)
  • Coward, Eivind (author)
  • Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xohlcl (author)
  • Göteborgs universitetCore Facilities, Bioinformatics (creator_code:org_t)

Related titles

  • In:NATURE AGING2662-8465

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