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  • Holmberg, LarsUppsala University,King's College London (author)

Cumulative incidence of and risk factors for BCG infection after adjuvant BCG instillations

  • Article/chapterEnglish2024

Publisher, publication year, extent ...

  • Blackwell Publishing,2024

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/336083
  • https://gup.ub.gu.se/publication/336083URI
  • https://doi.org/10.1111/bju.16303DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-111956URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-221629URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-201842URI
  • https://lup.lub.lu.se/record/b7dabbc7-7bb2-41f3-b9e8-bedd4ceddf2eURI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:155167626URI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Vetenskapsrdet [CAN 2022/1971, CAN 2023/2807]; Swedish Cancer Society [2021-00859]; Swedish Research Council
  • ObjectivesTo investigate the cumulative incidence proportion of disseminated or local Bacillus Calmette-Guerin (BCG) infections after adjuvant BCG instillations in patients with non-muscle-invasive bladder cancer (NMIBC).Patients and MethodsWe analysed the timing and occurrence of BCG infections and absolute and relative risk in relation to patient characteristics available in the Swedish nationwide database 'BladderBaSe 2.0'. The cumulative incidence proportion of a BCG infection was indicated by a reported diagnosis of tuberculosis (TB) in the patient registry or filing a prescription for tuberculostatic drugs.ResultsThe cumulative incidence proportion was 1.1% at the 5-year follow-up in 5033 patients exposed to adjuvant BCG instillations. The incidence rate was highest during the first 2 years after start of BCG instillations. Women had a lower risk than men (hazard ratio 0.23, 95% confidence interval 0.07-0.74). Age and calendar time at diagnosis, comorbidity, tumour risk group, previous medication with corticosteroids, immunosuppressive drugs, or time between transurethral resection of the bladder tumour and commencing the adjuvant BCG instillation were not associated with risk.ConclusionsThese data further supports that the overall risk of a BCG infection after BCG-instillation treatment for NMIBC is low. The great majority of infections occur in the first 2 years, calling for an awareness of the diverse symptoms of BCG infection during this period. We provide evidence for male sex as a risk factor; however, the statistical precision is low and with a risk of selection bias, making it difficult to rule out the other suggested risk factors without further studies with different approaches.

Subject headings and genre

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  • Skogmar, StenLund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups(Swepub:lu)med-ssg (author)
  • Garmo, HansUppsala University,King's College London (author)
  • Hagberg, OskarLund University,Lunds universitet,Urologi - blåscancer, Malmö,Forskargrupper vid Lunds universitet,Urology - urothelial cancer, Malmö,Lund University Research Groups(Swepub:lu)mats-oha (author)
  • Häggström, ChristelUppsala University,Umeå University,Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Department of Surgical Sciences, Uppsala University, Uppsala; Northern Register Centre, Umeå universitet, Umeå, Sverige,Uppsala Univ, Sweden; Umea Univ, Sweden(Swepub:umu)chlham02 (author)
  • Gardmark, TrulsKarolinska Institutet (author)
  • Ströck, VivekaGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology,Department of Urology, Sahlgrenska University Hospital and Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden(Swepub:gu)xstrvi (author)
  • Aljabery, FirasLinköping University,Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland(Swepub:liu)firab05 (author)
  • Jahnson, StaffanLinköping University,Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland(Swepub:liu)staja74 (author)
  • Hosseini, AbolfazlKarolinska Institute,Danderyd Hospital (author)
  • Jerlström, Tomas,1969-Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Urology,Orebro Univ, Sweden(Swepub:oru)tjm (author)
  • Sherif, AmirUmeå University,Umeå universitet,Urologi och andrologi,Umea Univ, Sweden(Swepub:umu)amsh0008 (author)
  • Söderkvist, KarinUmeå University,Umeå universitet,Institutionen för strålningsvetenskaper,Umea Univ, Sweden(Swepub:umu)kansom97 (author)
  • Ullen, AndersKarolinska Institutet,Karolinska Institute (author)
  • Malmstrom, Per-UnoUppsala University (author)
  • Liedberg, FredrikLund University,Lunds universitet,Urologi - blåscancer, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urinblåsecancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Urology - urothelial cancer, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Urothelial cancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)urok-fli (author)
  • Uppsala UniversityKing's College London (creator_code:org_t)

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  • In:BJU INTERNATIONAL: Blackwell Publishing1464-40961464-410X

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