Search: L773:1872 6216 OR L773:0047 6374 >
A feasibility study...
A feasibility study of the combination of intranasal insulin with oral semaglutide for cognition in older adults with metabolic syndrome at high dementia risk- Study rationale and design
-
Davidy, Tal (author)
-
Yore, Iscka (author)
-
Cukierman-Yaffe, Tali (author)
-
show more...
-
Ravona-Springer, Ramit (author)
-
Livny, Abigail (author)
-
Lesman-Segev, Orit H. (author)
-
Azuri, Yossi (author)
-
Carmichael, Owen (author)
-
Kapogiannis, Dimitrios (author)
-
- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
Lin, Hung Mo (author)
-
Sano, Mary (author)
-
Beeri, Michal Schnaider (author)
-
show less...
-
(creator_code:org_t)
- 2024
- 2024
- English.
-
In: Mechanisms of Ageing and Development. - 0047-6374 .- 1872-6216. ; 218
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Introduction: We present the rationale and design of a double-blind placebo-controlled feasibility trial combining intranasal insulin (INI) with semaglutide, a GLP-1 receptor agonist, to improve cognition in older adults with metabolic syndrome (MetS) and mild cognitive impairment (MCI). Since both INI and dulaglutide have beneficial effects on the cerebrovascular disease (CVD), we anticipate that improved CVD will underlie the hypothesized cognitive benefits. Methods: This 12-months trial will include 80 older adults aged > 60 with MetS and MCI, randomized to 4 groups: INI/oral semaglutide, intranasal placebo/oral semaglutide, INI/oral placebo, and intranasal placebo/oral placebo. Feasibility of combining INI with semaglutide will be tested by examining the ease of use of INI (20IU, twice/day) with semaglutide (14 once daily), adherence, and safety profile are the efficacy of combination therapy on global cognition and neurobiological markers: cerebral blood flow, cerebral glucose utilization, white matter hyperintensities, Alzheimer's related blood biomarkers and expression of insulin signaling proteins measured in brain-derived exosomes. Efficacy will be assessed for the intent-to-treat sample. Discussion: This feasibility study is anticipated to provide the basis for a multi-center large-scale randomized clinical trial (RCT) of the cognitive benefits of the combination of INI with semaglutide in individuals enriched for CVD and at high dementia risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Cerebral blood flow
- Cognition
- Dulaglutide
- Intranasal insulin
- Metabolic syndrome
- Mild cognitive impairment
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Davidy, Tal
-
Yore, Iscka
-
Cukierman-Yaffe, ...
-
Ravona-Springer, ...
-
Livny, Abigail
-
Lesman-Segev, Or ...
-
show more...
-
Azuri, Yossi
-
Carmichael, Owen
-
Kapogiannis, Dim ...
-
Zetterberg, Henr ...
-
Lin, Hung Mo
-
Sano, Mary
-
Beeri, Michal Sc ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
- Articles in the publication
-
Mechanisms of Ag ...
- By the university
-
University of Gothenburg