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Decreased neutrophi...
Decreased neutrophil function in newly diagnosed multiple myeloma patients is restored with lenalidomide therapy
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- Askman, Sandra (author)
- Lund University,Lunds universitet,Myelomgruppen,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Myeloma research group,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Westerlund, Julia (author)
- Lund University,Lunds universitet,Myelomgruppen,Forskargrupper vid Lunds universitet,Myeloma research group,Lund University Research Groups
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- Pettersson, Åsa (author)
- Lund University,Lunds universitet,Autoimmunitet och njursjukdomar,Forskargrupper vid Lunds universitet,Myelomgruppen,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Autoimmunity and kidney diseases,Lund University Research Groups,Myeloma research group,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Hellmark, Thomas (author)
- Lund University,Lunds universitet,Autoimmunitet och njursjukdomar,Forskargrupper vid Lunds universitet,Autoimmunity and kidney diseases,Lund University Research Groups,Skåne University Hospital
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- Johansson, Åsa (author)
- Skåne University Hospital
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- Wichert, Stina (author)
- Lund University,Lunds universitet,Myelomgruppen,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Myeloma research group,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Hansson, Markus (author)
- University of Gothenburg,Lund University,Lunds universitet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Myelomgruppen,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Myeloma research group,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: EUROPEAN JOURNAL OF HAEMATOLOGY. - 0902-4441 .- 1600-0609.
- Related links:
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- ObjectivesBacterial infections are common and a major cause of morbidity and mortality in multiple myeloma (MM). We have investigated the function of polymorphonuclear leukocyte (PMN), the immune system's first line of defense against bacteria, in peripheral blood (PB) and bone marrow (BM) samples from patients with newly diagnosed MM (NDMM), smoldering MM (SMM), monoclonal gammopathy of undetermined significance (MGUS) and healthy controls.MethodsPhagocytosis and oxidative burst in PMN cells from patients and healthy donors were investigated using PhagoTest and PhagoBurst assay.ResultsPMN from NDMM, SMM, and MGUS patients had reduced phagocytosis and oxidative burst ability compared with healthy controls. The dysfunction was most prominent in BM samples from MM, SMM, and MGUS patients. Importantly the reduced phagocytosis in MM patients was restored in patients on lenalidomide therapy. Consistently the ability of Escherichia coli stimulated oxidative burst in BM was reduced for the MM, SMM, and MGUS cohort in contrast to the healthy controls and the patients on lenalidomide treatment.ConclusionOur results show that MM patients have neutrophil dysfunction that could contribute to susceptibility for bacterial infections and that lenalidomide therapy was associated with restored PMN function.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- lenalidomide
- MGUS
- multiple myeloma
- neutrophils
- oxidative burst
- phagocytosis
- PMN
- SMM
Publication and Content Type
- ref (subject category)
- art (subject category)
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