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  • Eggers, Kai M.,1962-Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR) (author)

Diagnostic and prognostic performance of the ratio between high-sensitivity cardiac troponin I and troponin T in patients with chest pain.

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-11-01
  • Public Library of Science (PLoS),2022

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/336995
  • https://gup.ub.gu.se/publication/336995URI
  • https://doi.org/10.1371/journal.pone.0276645DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-489749URI

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  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Elevations of high-sensitivity cardiac troponin (hs-cTn) concentrations not related to type 1 myocardial infarction are common in chest pain patients presenting to emergency departments. The discrimination of these patients from those with type 1 myocardial infarction (MI) is challenging and resource-consuming. We aimed to investigate whether the hs-cTn I/T ratio might provide diagnostic and prognostic increment in this context.We calculated the hs-cTn I/T ratio in 888 chest pain patients having hs-cTnI (Abbott Laboratories) or hs-cTnT (Roche Diagnostics) concentrations above the respective 99th percentile at 2 hours from presentation. All patients were followed for one year regarding mortality.The median hs-cTn I/T ratio was 3.45 (25th, 75th percentiles 1.80-6.59) in type 1 MI patients (n = 408 ☯46.0%]), 1.18 (0.81-1.90) in type 2 MI patients (n = 56 ☯6.3%]) and 0.67 (0.39-1.12) in patients without MI. The hs-cTn I/T ratio provided good discrimination of type 1 MI from no type 1 MI (area under the receiver-operator characteristic curve 0.89 ☯95% confidence interval 0.86-0.91]), of type 1 MI from type 2 MI (area under the curve 0.81 ☯95% confidence interval 0.74-0.87]), and was associated with type 1 MI in adjusted analyses. The hs-cTn I/T ratio provided no consistent prognostic value.The hs-cTn I/T ratio appears to be useful for early diagnosis of type 1 MI and its discrimination from type 2 MI in chest pain patients presenting with elevated hs-cTn. Differences in hs-cTn I/T ratio values may reflect variations in hs-cTn release mechanisms in response to different types of myocardial injury.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Hammarsten, OlaGothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine,Department of Clinical Chemistry, Sahlgrenska University Hopsital, Göteborg, Sweden(Swepub:gu)xhamol (author)
  • Aldous, Sally JDepartment of Cardiology, Christchurch Hospital, Christchurch, New Zealand (author)
  • Cullen, LouiseEmergency Department, Royal Brisbane and Women’s Hospital, Brisbane, Australia (author)
  • Greenslade, Jaimi HEmergency Department, Royal Brisbane and Women’s Hospital, Brisbane, Australia (author)
  • Lindahl, Bertil,1957-Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)belin227 (author)
  • Parsonage, William ADepartment of Cardiology, Royal Brisbane and Women’s Hospital, Brisbane, Australia (author)
  • Pemberton, Christopher JChristchurch Heart Institute, Department of Medicine, University of Ontago, Christchurch, New Zealand (author)
  • Pickering, John WChristchurch Heart Institute, Department of Medicine, University of Ontago, Christchurch, New Zealand, Emergency Department, Christchurch Hospital, Christchurch, New Zealand (author)
  • Richards, A MarkChristchurch Heart Institute, Department of Medicine, University of Ontago, Christchurch, New Zealand, Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore (author)
  • Troughton, Richard WChristchurch Heart Institute, Department of Medicine, University of Ontago, Christchurch, New Zealand (author)
  • Than, Martin PEmergency Department, Christchurch Hospital, Christchurch, New Zealand (author)
  • Uppsala universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

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  • In:PloS one: Public Library of Science (PLoS)17:111932-6203

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