Search: onr:"swepub:oai:gup.ub.gu.se/336995" >
Diagnostic and prog...
-
Eggers, Kai M.,1962-Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR)
(author)
Diagnostic and prognostic performance of the ratio between high-sensitivity cardiac troponin I and troponin T in patients with chest pain.
- Article/chapterEnglish2022
Publisher, publication year, extent ...
-
2022-11-01
-
Public Library of Science (PLoS),2022
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/336995
-
https://gup.ub.gu.se/publication/336995URI
-
https://doi.org/10.1371/journal.pone.0276645DOI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-489749URI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Elevations of high-sensitivity cardiac troponin (hs-cTn) concentrations not related to type 1 myocardial infarction are common in chest pain patients presenting to emergency departments. The discrimination of these patients from those with type 1 myocardial infarction (MI) is challenging and resource-consuming. We aimed to investigate whether the hs-cTn I/T ratio might provide diagnostic and prognostic increment in this context.We calculated the hs-cTn I/T ratio in 888 chest pain patients having hs-cTnI (Abbott Laboratories) or hs-cTnT (Roche Diagnostics) concentrations above the respective 99th percentile at 2 hours from presentation. All patients were followed for one year regarding mortality.The median hs-cTn I/T ratio was 3.45 (25th, 75th percentiles 1.80-6.59) in type 1 MI patients (n = 408 ☯46.0%]), 1.18 (0.81-1.90) in type 2 MI patients (n = 56 ☯6.3%]) and 0.67 (0.39-1.12) in patients without MI. The hs-cTn I/T ratio provided good discrimination of type 1 MI from no type 1 MI (area under the receiver-operator characteristic curve 0.89 ☯95% confidence interval 0.86-0.91]), of type 1 MI from type 2 MI (area under the curve 0.81 ☯95% confidence interval 0.74-0.87]), and was associated with type 1 MI in adjusted analyses. The hs-cTn I/T ratio provided no consistent prognostic value.The hs-cTn I/T ratio appears to be useful for early diagnosis of type 1 MI and its discrimination from type 2 MI in chest pain patients presenting with elevated hs-cTn. Differences in hs-cTn I/T ratio values may reflect variations in hs-cTn release mechanisms in response to different types of myocardial injury.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Hammarsten, OlaGothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine,Department of Clinical Chemistry, Sahlgrenska University Hopsital, Göteborg, Sweden(Swepub:gu)xhamol
(author)
-
Aldous, Sally JDepartment of Cardiology, Christchurch Hospital, Christchurch, New Zealand
(author)
-
Cullen, LouiseEmergency Department, Royal Brisbane and Women’s Hospital, Brisbane, Australia
(author)
-
Greenslade, Jaimi HEmergency Department, Royal Brisbane and Women’s Hospital, Brisbane, Australia
(author)
-
Lindahl, Bertil,1957-Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)belin227
(author)
-
Parsonage, William ADepartment of Cardiology, Royal Brisbane and Women’s Hospital, Brisbane, Australia
(author)
-
Pemberton, Christopher JChristchurch Heart Institute, Department of Medicine, University of Ontago, Christchurch, New Zealand
(author)
-
Pickering, John WChristchurch Heart Institute, Department of Medicine, University of Ontago, Christchurch, New Zealand, Emergency Department, Christchurch Hospital, Christchurch, New Zealand
(author)
-
Richards, A MarkChristchurch Heart Institute, Department of Medicine, University of Ontago, Christchurch, New Zealand, Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore
(author)
-
Troughton, Richard WChristchurch Heart Institute, Department of Medicine, University of Ontago, Christchurch, New Zealand
(author)
-
Than, Martin PEmergency Department, Christchurch Hospital, Christchurch, New Zealand
(author)
-
Uppsala universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Related titles
-
In:PloS one: Public Library of Science (PLoS)17:111932-6203
Internet link
Find in a library
-
PloS one
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Eggers, Kai M., ...
-
Hammarsten, Ola
-
Aldous, Sally J
-
Cullen, Louise
-
Greenslade, Jaim ...
-
Lindahl, Bertil, ...
-
show more...
-
Parsonage, Willi ...
-
Pemberton, Chris ...
-
Pickering, John ...
-
Richards, A Mark
-
Troughton, Richa ...
-
Than, Martin P
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Medical Biotechn ...
-
and Biomedical Labor ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
- Articles in the publication
-
PloS one
- By the university
-
University of Gothenburg
-
Uppsala University