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Associations of the...
Associations of the glycaemic index and the glycaemic load with risk of type 2 diabetes in 127594 people from 20 countries (PURE): a prospective cohort study
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Miller, Victoria (författare)
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Jenkins, David A. (författare)
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Dehghan, Mahshid (författare)
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visa fler...
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Srichaikul, Kristie (författare)
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Rangarajan, Sumathy (författare)
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Mente, Andrew (författare)
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Mohan, Viswanathan (författare)
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Swaminathan, Sumathi (författare)
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Ismail, Rosnah (författare)
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Luz Diaz, Maria (författare)
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Ravindran, Rekha M. (författare)
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Zatonska, Katarzyna (författare)
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Bahonar, Ahmad (författare)
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Altuntas, Yuksel (författare)
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Khatib, Rasha (författare)
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Lopez-Jaramillo, Patricio (författare)
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Yusufali, Afzalhussein (författare)
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Yeates, Karen (författare)
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Chifamba, Jephat (författare)
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Iqbal, Romaina (författare)
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Yusuf, Rita (författare)
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Catherina Swart, Elizabeth (författare)
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Bo, Hu (författare)
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Han, Guoliang (författare)
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Li, Xiaocong (författare)
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Alhabib, Khalid F. (författare)
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- Rosengren, Annika, 1951 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Avezum, Alvaro (författare)
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Lanas, Fernando (författare)
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Yusuf, Salim (författare)
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visa färre...
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: The Lancet Diabetes and Endocrinology. - 2213-8587 .- 2213-8595. ; 12, s. 330-338
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background: The association between the glycaemic index and the glycaemic load with type 2 diabetes incidence is controversial. We aimed to evaluate this association in an international cohort with diverse glycaemic index and glycaemic load diets. Methods: The PURE study is a prospective cohort study of 127 594 adults aged 35–70 years from 20 high-income, middle-income, and low-income countries. Diet was assessed at baseline using country-specific validated food frequency questionnaires. The glycaemic index and the glycaemic load were estimated on the basis of the intake of seven categories of carbohydrate-containing foods. Participants were categorised into quintiles of glycaemic index and glycaemic load. The primary outcome was incident type 2 diabetes. Multivariable Cox Frailty models with random intercepts for study centre were used to calculate hazard ratios (HRs). Findings: During a median follow-up of 11·8 years (IQR 9·0–13·0), 7326 (5·7%) incident cases of type 2 diabetes occurred. In multivariable adjusted analyses, a diet with a higher glycaemic index was significantly associated with a higher risk of diabetes (quintile 5 vs quintile 1; HR 1·15 [95% CI 1·03–1·29]). Participants in the highest quintile of the glycaemic load had a higher risk of incident type 2 diabetes compared with those in the lowest quintile (HR 1·21, 95% CI 1·06–1·37). The glycaemic index was more strongly associated with diabetes among individuals with a higher BMI (quintile 5 vs quintile 1; HR 1·23 [95% CI 1·08–1·41]) than those with a lower BMI (quintile 5 vs quintile 1; 1·10 [0·87–1·39]; p interaction=0·030). Interpretation: Diets with a high glycaemic index and a high glycaemic load were associated with a higher risk of incident type 2 diabetes in a multinational cohort spanning five continents. Our findings suggest that consuming low glycaemic index and low glycaemic load diets might prevent the development of type 2 diabetes. Funding: Full funding sources are listed at the end of the Article.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
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Miller, Victoria
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Jenkins, David A ...
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Dehghan, Mahshid
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Srichaikul, Kris ...
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Rangarajan, Suma ...
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Mente, Andrew
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visa fler...
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Mohan, Viswanath ...
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Swaminathan, Sum ...
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Ismail, Rosnah
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Luz Diaz, Maria
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Ravindran, Rekha ...
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Zatonska, Katarz ...
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Bahonar, Ahmad
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Altuntas, Yuksel
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Khatib, Rasha
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Lopez-Jaramillo, ...
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Yusufali, Afzalh ...
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Yeates, Karen
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Chifamba, Jephat
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Iqbal, Romaina
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Yusuf, Rita
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Catherina Swart, ...
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Bo, Hu
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Han, Guoliang
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Li, Xiaocong
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Alhabib, Khalid ...
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Rosengren, Annik ...
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Avezum, Alvaro
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Lanas, Fernando
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Yusuf, Salim
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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The Lancet Diabe ...
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Göteborgs universitet