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Long-term ambient a...
Long-term ambient air pollution and coronary atherosclerosis: Results from the Swedish SCAPIS study.
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- Kilbo Edlund, Karl (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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- Andersson, Eva M., 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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Asker, Christian (author)
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- Barregård, Lars, 1948 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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- Bergström, Göran, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Center for Cardiovascular and Metabolic Research (CMR),Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Wallenberglaboratoriet,Institute of Medicine,Institute of Neuroscience and Physiology, Department of Physiology,Institute of Medicine, Department of Molecular and Clinical Medicine,Institute of Neuroscience and Physiology, Department of Pharmacology,Wallenberg Laboratory
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Eneroth, Kristina (author)
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Jernberg, Tomas (author)
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Ljunggren, Stefan (author)
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- Molnár, Peter, 1967 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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Sommar, Johan Nilsson (author)
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Oudin, Anna (author)
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Pershagen, Göran (author)
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Persson, Åsa (author)
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Pyko, Andrei (author)
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Spanne, Mårten (author)
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Tondel, Martin (author)
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Ögren, Mikael (author)
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Ljungman, Petter (author)
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- Stockfelt, Leo, 1981 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Atherosclerosis. - 1879-1484.
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Despite firm evidence for an association between long-term ambient air pollution exposure and cardiovascular morbidity and mortality, results from epidemiological studies on the association between air pollution exposure and atherosclerosis have not been consistent. We investigated associations between long-term low-level air pollution exposure and coronary atherosclerosis.We performed a cross-sectional analysis in the large Swedish CArdioPulmonary bioImaging Study (SCAPIS, n=30154), a random general population sample. Concentrations of total and locally emitted particulate matter <2.5μm (PM2.5), <10μm (PM10), and nitrogen oxides (NOx) at the residential address were modelled using high-resolution dispersion models. We estimated associations between air pollution exposures and segment involvement score (SIS), coronary artery calcification score (CACS), number of non-calcified plaques (NCP), and number of significant stenoses, using ordinal regression models extensively adjusted for potential confounders.Median 10-year average PM2.5 exposure was 6.2μg/m3 (range 3.5-13.4μg/m3). 51% of participants were women and 51% were never-smokers. None of the assessed pollutants were associated with a higher SIS or CACS. Exposure to PM2.5 was associated with NCP (adjusted OR 1.34, 95% CI 1.13, 1.58, per 2.05μg/m3). Associations with significant stenoses were inconsistent.In this large, middle-aged general population sample with low exposure levels, air pollution was not associated with measures of total burden of coronary atherosclerosis. However, PM2.5 appeared to be associated with a higher prevalence of non-calcified plaques. The results suggest that increased risk of early-stage atherosclerosis or rupture, but not increased total atherosclerotic burden, may be a pathway for long-term air pollution effects on cardiovascular disease.
Subject headings
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Meteorologi och atmosfärforskning (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Meteorology and Atmospheric Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Air pollution; Atherosclerosis; Cardiovascular diseases; Coronary artery disease; Nitrogen oxides; Particulate matter
Publication and Content Type
- ref (subject category)
- art (subject category)
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Kilbo Edlund, Ka ...
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Andersson, Eva M ...
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Asker, Christian
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Barregård, Lars, ...
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Bergström, Göran ...
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Eneroth, Kristin ...
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show more...
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Jernberg, Tomas
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Ljunggren, Stefa ...
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Molnár, Peter, 1 ...
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Sommar, Johan Ni ...
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Oudin, Anna
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Pershagen, Göran
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Persson, Åsa
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Pyko, Andrei
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Spanne, Mårten
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Tondel, Martin
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Ögren, Mikael
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Ljungman, Petter
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Stockfelt, Leo, ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Earth and Relate ...
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and Meteorology and ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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Atherosclerosis
- By the university
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University of Gothenburg