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Cyclopeptide alkalo...
Cyclopeptide alkaloids from the Greek shrub Paliurus spina-christi and their in silico binding affinity to Dipeptidyl Peptidase IV
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Amountzias, Vaios (författare)
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Abatis, Dennis (författare)
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- Drakopoulos, Antonios (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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Zoidis, Grigoris (författare)
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Aligiannis, Nektarios (författare)
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: NATURAL PRODUCT RESEARCH. - 1478-6419 .- 1478-6427.
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- A new cyclopeptide alkaloid, spinachristene A (1), along with two previously described, sanjoinenine (2) and oxyphylline C (3), were isolated from the fruits of Paliurus spina-christi Mill. All three metabolites are being isolated for the first time from the genus Paliurus. A model for the in silico binding affinity of compounds 1-3 to Dipeptidyl Peptidase IV (DPP4), which is related to type 2 diabetes (T2D), was developed. According to our model, compounds 1-3 were ranked in positions 9/12, 11/12 and 8/12, respectively and are predicted to exhibit significant affinity to DPP4, in the range of low 2-digit mu M.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Nyckelord
- Cyclopeptide alkaloids
- spinachristene A
- Paliurus spina-christi
- antidiabetic activity
- Dipeptidyl Peptidase IV
- in silico studies
- NMR
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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