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First year national Swedish paediatric Hba1c data are at the level of several intervention studies : Results from a Swedish nationwide diabetes register study

Steineck, Isabelle I. K. (författare)
Department of Endocrinology, Steno Diabetes Center Copenhagen, Gentofte, Denmark; Department of Endocrinology, Hvidovre Hospital, Copenhagen, Denmark,Steno Diabet Ctr Copenhagen, Denmark; Hvidovre Univ Hosp, Denmark
Anderzén, Johan (författare)
Department of Paediatrics, Ryhov County Hospital, Jönköping, Sweden,Ryhov Cty Hosp, Sweden
Eeg-Olofsson, Katarina (författare)
Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden; Center of Registers Västra Götaland, Gothenburg, Sweden,Univ Gothenburg, Sweden; Ctr Registers Vastra Gotaland, Sweden
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Ekelund, Jan (författare)
Center of Registers Västra Götaland, Gothenburg, Sweden,Ctr Registers Vastra Gotaland, Sweden
Gudbjörnsdottir, Soffia (författare)
Center of Registers Västra Götaland, Gothenburg, Sweden,Ctr Registers Vastra Gotaland, Sweden
Hanberger, Lena (författare)
Linköpings universitet,Avdelningen för omvårdnad och reproduktiv hälsa,Medicinska fakulteten,Region Östergötland, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus
Nåtman, Jonatan (författare)
Center of Registers Västra Götaland, Gothenburg, Sweden,Ctr Registers Vastra Gotaland, Sweden
Pundziute Lyckå, Auste (författare)
Sahlgrenska Academy, Institute of Clinical Sciences, University of Gothenburg, Sweden; Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden,Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden
Samuelsson, Ulf (författare)
Department of Paediatrics, Linköping, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden,PING Univ, Sweden
Särnblad, Stefan, 1963- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Department of Paediatrics, Örebro University Hospital, Örebro, Sweden,Orebro Univ Hospitalrebro, Sweden
Åkesson, Karin (författare)
Department of Paediatrics, Ryhov County Hospital, Jönköping, Sweden; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden,Ryhov Cty Hosp, Sweden
Hanas, Ragnar (författare)
Sahlgrenska Academy, Institute of Clinical Sciences, University of Gothenburg, Sweden; Department of Paediatrics, NU Hospital Group, Uddevalla Hospital, Uddevalla, Sweden,Univ Gothenburg, Sweden
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 (creator_code:org_t)
Elsevier, 2024
2024
Engelska.
Ingår i: Diabetes Research and Clinical Practice. - : Elsevier. - 0168-8227 .- 1872-8227. ; 216
Relaterad länk:
https://doi.org/10.1...
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https://urn.kb.se/re...
https://doi.org/10.1...
https://urn.kb.se/re...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • AIMS/HYPOTHESIS: To study the progression of HbA1c after diagnosis of type 1 diabetes in children and adolescents during 2010-2019 with emphasis on HbA1c nadir 3-6 months after onset.METHODS: Partial funding was secured for this study. The Swedish paediatric diabetes quality register SWEDIABKIDS has >95 % coverage of type 1 diabetes up to 18 years. A mixed model for repeated measurements was used to estimate differences in HbA1c between onset year periods.RESULTS: We followed 6,891 patients over two years from onset (48,292 HbA1c values). We found a gradual decrease in mean HbA1c 24 months after onset from 56.0 mmol/mol (7.28 %) in 2010/11 to 50.5 mmol/mol (6.77 %) in 2018/19, which is at the level of several recent intervention studies. The initial drop in HbA1c from onset until 3 and 6 months has become more pronounced in recent years. There was a significant positive correlation between HbA1c at 3 and 6 months with 12, 18 and 24 months. Percentage of severe hypoglycaemic coma was higher (5.1 % vs 3.4 %; p = 0.023) in 2010/2011 than 2018/2019, but the absolute risk of ketoacidosis was essentially unchanged, (1.5 % to 0.8 %, p = 0.110)Conclusions/interpretation: There was a continuous decrease in HbA1c over the study period 2010-2019, which coincides in time with an increased use of diabetes technology and lowering the HbA1c target to 48 mmol/mol (6.5 %). The decrease in 2-year HbA1c was preceded by a lower HbA1c nadir, which may set the trajectories for coming HbA1c and be a modifiable factor for a long-term improvement in metabolic control.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

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