Future perspective for the application of predictive biomarkertesting in advanced stage non-small cell lung cance

For patients with advanced stage non-small cell lung cancer (NSCLC), treatment strategies have changed significantly due to the introduction of targeted therapies and immunotherapy. In the last few years, we have seen an explosive growth of newly introduced targeted therapies in oncology and this development is expected to continue in the future. Besides primary targetable aberrations, emerging diagnostic biomarkers also include relevant co-occurring mutations and resistance mechanisms involved in disease progression, that have impact on optimal treatment management. Toaccommodate testing of pending biomarkers, it is necessary to establish routine large-panel next-generationsequencing (NGS) for all patients with advanced stage NSCLC. For cost-effectiveness and accessibility, it is recommended to implement predictive molecular testing using large-panel NGS in a dedicated, centralized expert laboratory within a regional oncology network. The central molecular testing center should host a regional Molecular Tumor Board and function as a hub for interpretation of rare and complex testing results and clinical decision-making. Copyright (c) 2024 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Timens, Wim (author)
Bayle, Arnaud (author)
Botling, Johan,1964Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine(Swepub:gu)xbotlj (author)
Brcic, Luka (author)
Buettner, Reinhard (author)
Fernandes, Maria Gabriela O. (author)
Havel, Libor (author)
Hochmair, Maximilian (author)
Hofman, Paul (author)
Janssens, Annelies (author)
van Kempe, Leon (author)
Kern, Izidor (author)
Machado, Jose Carlos (author)
Mohorcic, Katja (author)
Popat, Sanjay (author)
Ryska, Ales (author)
Wolf, Juergen (author)
Schuuring, Ed (author)
van der Wekken, Anthonie J. (author)
Göteborgs universitetInstitutionen för biomedicin, avdelningen för laboratoriemedicin (creator_code:org_t)

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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