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  • de Jager, Vincent D.Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands (författare)

Developments in predictive biomarker testing and targeted therapy in advanced stage non-small cell lung cancer and their application across European countries

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • Elsevier,2024
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-222297
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-222297URI
  • https://doi.org/10.1016/j.lanepe.2024.100838DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:for swepub-publicationtype

Anmärkningar

  • In the past two decades, the treatment of metastatic non-small cell lung cancer (NSCLC), has undergone significant changes due to the introduction of targeted therapies and immunotherapy. These advancements have led to the need for predictive molecular tests to identify patients eligible for targeted therapy. This review provides an overview of the development and current application of targeted therapies and predictive biomarker testing in European patients with advanced stage NSCLC. Using data from eleven European countries, we conclude that recommendations for predictive testing are incorporated in national guidelines across Europe, although there are differences in their comprehensiveness. Moreover, the availability of recently EMA-approved targeted therapies varies between European countries. Unfortunately, routine assessment of national/regional molecular testing rates is limited. As a result, it remains uncertain which proportion of patients with metastatic NSCLC in Europe receive adequate predictive biomarker testing. Lastly, Molecular Tumor Boards (MTBs) for discussion of molecular test results are widely implemented, but national guidelines for their composition and functioning are lacking. The establishment of MTB guidelines can provide a framework for interpreting rare or complex mutations, facilitating appropriate treatment decision-making, and ensuring quality control.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Timens, WimDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands (författare)
  • Bayle, ArnaudOncostat U1018, Inserm, Paris-Saclay University, Gustave Roussy, Villejuif, France (författare)
  • Botling, JohanDepartment of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy of University of Gothenburg, Gothenburg, Sweden (författare)
  • Brcic, LukaDiagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria (författare)
  • Büttner, ReinhardInstitute of Medical Genetics and Applied Genomics, University of Tuebingen, Tuebingen, Germany (författare)
  • Fernandes, Maria Gabriela O.Pulmonology Department, Centro Hospitalar Universitário de São João, Porto, Portugal (författare)
  • Havel, LiborCharles University and Thomayer Hospital, Prague, Czech Republic (författare)
  • Hochmair, Maximilian J.Karl Landsteiner Institute of Lung Research and Pulmonary Oncology, Klinik Floridsdorf, Vienna, Austria; Department of Respiratory and Critical Care Medicine, Klinik Floridsdorf, Vienna Healthcare Group, Vienna, Austria (författare)
  • Hofman, PaulIHU RespirERA, FHU OncoAge, Nice University Hospital, Côte d'Azur University, Nice, France (författare)
  • Janssens, AnneliesDepartment of Oncology, University Hospital Antwerp, University of Antwerp, Edegem, Belgium (författare)
  • Johansson, MikaelUmeå universitet,Onkologi(Swepub:umu)mijo0025 (författare)
  • van Kempen, LéonDepartment of Pathology, University Hospital Antwerp, University of Antwerp, Edegem, Belgium (författare)
  • Kern, IzidorLaboratory for Cytology and Pathology, University Clinic Golnik, Golnik, Slovenia (författare)
  • Lopez-Rios, FernandoHospital Universitario 12 de Octubre, Universidad Complutense de Madrid, Research Institute Hospital 12 de Octubre (i+12), Ciberonc, Madrid, Spain (författare)
  • Lüchtenborg, MargreetNational Disease Registration Service, NHS England, London, United Kingdom; Centre for Cancer, Society & Public Health, King's College London, London, United Kingdom (författare)
  • Machado, José CarlosInstitute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal; Faculty of Medicine of the University of Porto, Institute for Research and Innovation in Health (i3S), Porto, Portugal (författare)
  • Mohorcic, KatjaUniversity Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia (författare)
  • Paz-Ares, LuisHospital Universitario 12 de Octubre, Universidad Complutense de Madrid, H12O-CNIO Lung Cancer Clinical Research Unit, Research Institute Hospital 12 de Octubre (i+12)/Spanish National Cancer Research Center (CNIO), Ciberonc, Madrid, Spain (författare)
  • Popat, SanjayLung Unit, Royal Marsden NHS Trust, London, United Kingdom (författare)
  • Ryška, AlešThe Fingerland Department of Pathology, Charles University Medical Faculty and University Hospital, Czech Republic (författare)
  • Taniere, PhillipeDepartment of Histopathology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom (författare)
  • Wolf, JürgenLung Cancer Group Cologne, Department I for Internal Medicine and Center for Integrated Oncology Cologne/Bonn, University Hospital Cologne, Cologne, Germany (författare)
  • Schuuring, EdDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands (författare)
  • van der Wekken, Anthonie J.Department of Pulmonary Diseases and Tuberculosis, University Medical Center Groningen, University of Groningen, Groningen, Netherlands (författare)
  • Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsOncostat U1018, Inserm, Paris-Saclay University, Gustave Roussy, Villejuif, France (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:The Lancet Regional Health: Elsevier382666-7762

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