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Cancer as a risk fa...
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Hefling, L A
(författare)
Cancer as a risk factor for long-term cognitive deficits and dementia.
- Artikel/kapitelEngelska2005
Förlag, utgivningsår, omfång ...
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2005-06-01
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Oxford University Press (OUP),2005
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/33966
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https://gup.ub.gu.se/publication/33966URI
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https://doi.org/10.1093/jnci/dji137DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1941922URI
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Previous studies have shown that cancer survivors frequently experience short-term cognitive deficits, but it is unknown how long these deficits last or whether they worsen over time. Using a co-twin control design, the cognitive function of 702 cancer survivors aged 65 years and older was compared with that of their cancer-free twins. Dementia rates were also compared in 486 of the twin pairs discordant for cancer. Cancer survivors overall, as well as individuals who had survived cancer for 5 or more years before cognitive testing, were more likely than their co-twins to have cognitive dysfunction (odds ratio [OR] = 2.10, 95% confidence interval [CI] = 1.36 to 3.24; P<.001; and OR = 2.71, 95% CI = 1.47 to 5.01; P<.001, respectively). Cancer survivors were also twice as likely to be diag-nosed with dementia as their co-twins, but this odds ratio did not reach statisti-cal significance (OR = 2.0, 95% CI = 0.86 to 4.67; P = .10). These results suggest that cancer patients are at increased risk for long-term cognitive dysfunction compared with individuals who have never had cancer, even after controlling for the influence of genetic factors and rearing environment.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Meyerowitz, B E
(författare)
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Hall, PKarolinska Institutet
(författare)
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Lichtenstein, PKarolinska Institutet
(författare)
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Johansson, BooGothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology(Swepub:gu)xjoboo
(författare)
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Pedersen, Nancy L.
(författare)
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Gatz, Margaret
(författare)
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Heflin, LH
(författare)
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Karolinska InstitutetPsykologiska institutionen
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of the National Cancer Institute: Oxford University Press (OUP)97:11, s. 854-8561460-21050027-8874
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