Gene profiling reveals increased expression of uteroglobin and other anti-inflammatory genes in glucocorticoid-treated nasal polyps.

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Gene profiling reveals increased expression of uteroglobin and other anti-inflammatory genes in glucocorticoid-treated nasal polyps.

Benson, Mikael, 1954 (author): Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics,University of Gothenburg,Malmö University Hospital, Sweden

Carlsson, Lena M S, 1957 (author): Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital,Sahlgrenska University Hospital, Gothenburg, Sweden

Adner, Mikael (author): Lund University,Lunds universitet,Klinisk och experimentell allergiforskning,Laryngoesofagologi, allergi och livskvalitet,Forskargrupper vid Lunds universitet,Clinical and Experimental Allergy Research,Laryngoesophagology, Allergy and Life Quality,Lund University Research Groups,Malmö University Hospital, Sweden

Jernås, Margareta, 1961 (author): Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism,University of Gothenburg,Sahlgrenska University Hospital, Gothenburg, Sweden

Rudemo, Mats, 1937 (author): Gothenburg University,Göteborgs universitet,Institutionen för matematisk statistik,Department of Mathematical Statistics,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology,Chalmers University of Technology, Gothenburg, Sweden

Sjögren, Anders, 1979 (author): Chalmers tekniska högskola,Chalmers University of Technology,Chalmers University of Technology, Gothenburg, Sweden

Svensson, Per-Arne, 1969 (author): Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism,University of Gothenburg,Sahlgrenska University Hospital, Gothenburg, Sweden

Uddman, Rolf (author): Lund University,Lunds universitet,Klinisk och experimentell allergiforskning,Laryngoesofagologi, allergi och livskvalitet,Forskargrupper vid Lunds universitet,Clinical and Experimental Allergy Research,Laryngoesophagology, Allergy and Life Quality,Lund University Research Groups,Malmö University Hospital, Sweden

Cardell, Lars Olaf (author): Skånes universitetssjukhus (SUS),Skåne University Hospital,Malmö University Hospital, Sweden

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Elsevier BV, 2004
2004
English.
In: Journal of Allergy and Clinical Immunology. - : Elsevier BV. - 0091-6749 .- 1097-6825. ; 113:6, s. 1137-43

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Journal article (peer-reviewed)

Abstract Subject headings

BACKGROUND: Treatment with local glucocorticoids (GCs) decreases symptoms and the size of nasal polyps. This might depend on the downregulation of proinflammatory genes, as well as the upregulation of anti-inflammatory genes. OBJECTIVE: We sought to identify GC-regulated anti-inflammatory genes in nasal polyps. METHODS: Affymetrix DNA microarrays were used to analyze the expression of 22,283 genes in 4 nasal polyps before and after local treatment with fluticasone (400 microg/d). Expression of uteroglobin and mammaglobin B was analyzed with real-time PCR in 6 nasal polyps and in nasal biopsy specimens from 6 healthy control subjects. RESULTS: Two hundred three genes had changed in expression in treated polyps, and 139 had known functions: 54 genes were downregulated, and 85 were upregulated. Genes associated with inflammation constituted the largest single functional group. These genes affected key steps in inflammation (eg, immunoglobulin production; antigen processing and presentation; and the chemoattraction and activation of granulocytes, T cells, and B cells). Several proinflammatory genes were downregulated. In contrast, some anti-inflammatory genes were upregulated. The gene that increased most in terms of expression was uteroglobin. This was confirmed with real-time PCR. By contrast, expression of uteroglobin was lower in untreated polyps than in healthy nasal mucosa. Immunohistochemical investigation showed staining of uteroglobin in the epithelium and in seromucous glands in control subjects and in nasal polyps. CONCLUSION: Upregulation of anti-inflammatory genes, such as uteroglobin, might contribute to the effects of local treatment with GCs in nasal polyps.

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By the author/editor: Benson, Mikael, ...; Carlsson, Lena M ...; Adner, Mikael; Jernås, Margaret ...; Rudemo, Mats, 19 ...; Sjögren, Anders, ...; show more...; Svensson, Per-Ar ...; Uddman, Rolf; Cardell, Lars Ol ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Respiratory Medi ...

Articles in the publication: Journal of Aller ...

By the university: University of Gothenburg; Chalmers University of Technology; Lund University; Linköping University

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Gene profiling reveals increased expression of uteroglobin and other anti-inflammatory genes in glucocorticoid-treated nasal polyps.

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