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  • Cancello, Raffaella (author)

Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss.

  • Article/chapterEnglish2005

Publisher, publication year, extent ...

  • 2005

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/35872
  • https://gup.ub.gu.se/publication/35872URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • In human obesity, the stroma vascular fraction (SVF) of white adipose tissue (WAT) is enriched in macrophages. These cells may contribute to low-grade inflammation and to its metabolic complications. Little is known about the effect of weight loss on macrophages and genes involved in macrophage attraction. We examined subcutaneous WAT (scWAT) of 7 lean and 17 morbidly obese subjects before and 3 months after bypass surgery. Immunomorphological changes of the number of scWAT-infiltrating macrophages were evaluated, along with concomitant changes in expression of SVF-overexpressed genes. The number of scWAT-infiltrating macrophages before surgery was higher in obese than in lean subjects (HAM56+/CD68+; 22.6 +/- 4.3 vs. 1.4 +/- 0.6%, P < 0.001). Typical "crowns" of macrophages were observed around adipocytes. Drastic weight loss resulted in a significant decrease in macrophage number (-11.63 +/- 2.3%, P < 0.001), and remaining macrophages stained positive for the anti-inflammatory protein interleukin 10. Genes involved in macrophage attraction (monocyte chemotactic protein [MCP]-1, plasminogen activator urokinase receptor [PLAUR], and colony-stimulating factor [CSF]-3) and hypoxia (hypoxia-inducible factor-1alpha [HIF-1alpha]), expression of which increases in obesity and decreases after surgery, were predominantly expressed in the SVF. We show that improvement of the inflammatory profile after weight loss is related to a reduced number of macrophages in scWAT. MCP-1, PLAUR, CSF-3, and HIF-1alpha may play roles in the attraction of macrophages in scWAT.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Henega, Corneliu (author)
  • Viguerie, Nathalie (author)
  • Taleb, Soraya (author)
  • Poitou, Christine (author)
  • Rouault, Christine (author)
  • Coupaye, Muriel (author)
  • Pelloux, Veronique (author)
  • Hugol, Danielle (author)
  • Bouillot, Jean-Luc (author)
  • Bouloumié, Anne (author)
  • Barbatelli, Giorgio (author)
  • Cinti, Saverio (author)
  • Svensson, Per-Arne,1969Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism(Swepub:gu)xsvper (author)
  • Barsh, Gregory S. (author)
  • Zucker, Jean-Daniel (author)
  • Basdevant, Arnaud (author)
  • Langin, Dominique (author)
  • Clément, Karine (author)
  • Göteborgs universitetInstitutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism (creator_code:org_t)

Related titles

  • In:Diabetes54:8, s. 2277-860012-1797

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