Insulin resistance, glucose intolerance, physical activity and other risk factors for coronary heart disease in elderly men. The study of men born in 1913 and 1923.

BACKGROUND: We have previously shown that insulin is not a major risk factor for CHD. Our data have been re-analysed with longer follow-up and the homeostasis model assessment (HOMA) method. DESIGN: Prospective cohort study of 57- and 67-year-old men. METHODS: Insulin resistance was estimated with the HOMA equation. Standard methods were used to measure risk factors. The endpoint (CHD) was the combination of non-fatal myocardial infarction and fatal CHD during 13 years of follow-up. RESULTS: The risk of CHD increased 2.5-fold in known diabetics compared with those with normal glucose tolerance, 2.2-fold among those in the highest compared with the lowest quintile of insulin resistance, and 2.4-fold among those in the highest compared with the lowest quintile of fasting insulin. Increased physical activity decreased the risk of CHD by 65%. Cholesterol was also a significant risk factor for CHD but blood pressure, obesity and smoking were not related to the incidence of CHD. CONCLUSION: Insulin resistance is a significant risk factor for CHD. Whether it is a causal risk factor remains to be proven. Regular physical activity protects against CHD. PMID: 14555884 [PubMed - indexed for MEDLINE]

Bresäter, Lars-Einar,1949 (author)
Eriksson, Henry,1946 (author)
Hansson, Per-Olof,1958 (author)
Welin, Catharina,1945Gothenburg University,Göteborgs universitet,Institutionen för omvårdnad,Institute of Nursing(Swepub:gu)xwelca (author)
Rosengren, Annika,1951 (author)
Göteborgs universitetInstitutionen för omvårdnad (creator_code:org_t)

In:European Journal of Cardiovascular Prevention and Rehabilitation:10, s. 283-2881741-8267

By the author/editor: Welin, Lennart, ...; Bresäter, Lars-E ...; Eriksson, Henry, ...; Hansson, Per-Olo ...; Welin, Catharina ...; Rosengren, Annik ...

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