id:"swepub:oai:gup.ub.gu.se/38424"
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- Maisnier-Patin, Sophie (author)
Genomic buffering mitigates the effects of deleterious mutations in bacteria
- Article/chapterEnglish2005
Publisher, publication year, extent ...
- 2005-11-06
- Springer Science and Business Media LLC,2005
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- LIBRIS-ID:oai:gup.ub.gu.se/38424
- https://gup.ub.gu.se/publication/38424URI
- https://doi.org/10.1038/ng1676DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-76785URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:111648729URI
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- Language:English
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- The relationship between the number of randomly accumulated mutations in a genome and fitness is a key parameter in evolutionary biology1, 2, 3, 4, 5. Mutations may interact such that their combined effect on fitness is additive (no epistasis), reinforced (synergistic epistasis) or mitigated (antagonistic epistasis). We measured the decrease in fitness caused by increasing mutation number in the bacterium Salmonella typhimurium using a regulated, error-prone DNA polymerase (polymerase IV, DinB). As mutations accumulated, fitness costs increased at a diminishing rate. This suggests that random mutations interact such that their combined effect on fitness is mitigated and that the genome is buffered against the fitness reduction caused by accumulated mutations. Levels of the heat shock chaperones DnaK and GroEL increased in lineages that had accumulated many mutations, and experimental overproduction of GroEL further increased the fitness of lineages containing deleterious mutations. These findings suggest that overexpression of chaperones contributes to antagonistic epistasis
Subject headings and genre
- NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
- Molecular biology
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- Roth, John R. (author)
- Fredriksson, Åsa,1968Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi,Department of Cell and Molecular Biology(Swepub:gu)xfreas (author)
- Nyström, Thomas,1960Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi,Department of Cell and Molecular Biology(Swepub:gu)xnysth (author)
- Berg, OttoUppsala universitet,Molekylär evolution(Swepub:uu)obe15246 (author)
- Andersson, Dan I.Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)dan19789 (author)
- Göteborgs universitetInstitutionen för cell- och molekylärbiologi (creator_code:org_t)
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- In:Nature Genetics: Springer Science and Business Media LLC37:12, s. 1376-13791061-40361546-1718
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