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Cardiac concentric ...
Cardiac concentric remodelling induced by non-aromatizable (dihydro-)testosterone is antagonized by oestradiol in ovariectomized rats
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- Tivesten, Åsa, 1969 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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- Bollano, Entela, 1970 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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- Nyström, Henrik, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology
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- Alexanderson, Camilla, 1978 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology
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- Bergström, Göran, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology
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- Holmäng, Agneta, 1959 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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(creator_code:org_t)
- 2006
- 2006
- English.
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In: J Endocrinol. ; 189:3, s. 485-91
- Related links:
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https://gup.ub.gu.se...
Abstract
Subject headings
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- Previous studies on the cardiovascular effects of androgens in females, most of them using testosterone treatment, have yielded conflicting results. Testosterone is metabolized into oestradiol (E2) and dihydrotestosterone (DHT) within cardiovascular tissues. The aim of the present study was to explore the cardiovascular effects exerted by E2 and the non-aromatizable androgen DHT and to study possible interactions between these in female rats. Ovariectomized rats were treated with DHT, E2, or DHT+E2 for 6 weeks. DHT increased left-ventricular posterior wall thickness, assessed by echocardiography, whereas left-ventricular dimension, as well as total heart weight and calculated left-ventricular mass, were unchanged. DHT also increased the levels of insulin-like growth factor-I mRNA in the left ventricle. E2 abolished the effect of DHT on left-ventricular remodelling and insulin-like growth factor-I mRNA when the two treatments were given in combination. E2 also reduced androgen receptor mRNA levels in the heart. Neither E2 nor DHT changed blood pressure measured by telemetry. In conclusion, treatment with the endogenous non-aromatizable androgen DHT causes cardiac concentric remodelling in ovariectomized rats, possibly mediated by increased local levels of insulin-like growth factor-I. The effect of DHT on cardiac wall thickness was antagonized by E2, possibly through downregulation of cardiac androgen receptors. These mechanisms may be of importance for the concentric left-ventricular geometric pattern developing in women after menopause.
Keyword
- Androgens/*pharmacology
- Animals
- Dihydrotestosterone/*pharmacology
- Echocardiography
- Estradiol/*pharmacology
- Female
- Heart/*drug effects
- Heart Ventricles/drug effects/physiology/ultrasonography
- Insulin-Like Growth Factor I/genetics
- Ovariectomy
- RNA
- Messenger/analysis
- Rats
- Rats
- Sprague-Dawley
- Receptors
- Androgen/genetics/metabolism
- Reverse Transcriptase Polymerase Chain Reaction
Publication and Content Type
- ref (subject category)
- art (subject category)
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Tivesten, Åsa, 1 ...
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Bollano, Entela, ...
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Nyström, Henrik, ...
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Alexanderson, Ca ...
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Bergström, Göran ...
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Holmäng, Agneta, ...
- Articles in the publication
- J Endocrinol
- By the university
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University of Gothenburg