Antinuclear antibodies in the oldest-old women and men

Nilsson, Bengt-Olof,1954-Linköpings universitet,Infektionsmedicin,Hälsouniversitetet (författare)

The aim of this study was to compare the prevalence of antinuclear antibodies (ANA) in very old individuals (>/=86years of age) with healthy younger (18-68years) blood donors (n=200) regarding gender, health status, ratio of circulating CD4/CD8 cells and cytomegalovirus (CMV) serology. Frozen plasma was used for ANA detection in two study groups, i.e. 'OCTO' (97 persons aged 86-92years, 65% women) and 'NONA' (136 persons aged 86-95years, 70% women). OCTO participants were recruited on the basis that they were healthy or moderately healthy according to a selection protocol. No exclusion criteria regarding health status were applied in the NONA sample. The prevalence of ANA was significantly higher in the oldest-old samples compared to blood donors. There was no association between health status and the presence of ANA in the oldest-old. The difference across age was most pro-nounced in men, with low levels at younger age, whereas the prevalence among the oldest-old men reached similar levels as in women. There were no associations between the presence of ANA and CD4/CD8 ratio or with CMV status in the oldest-old. Our findings confirm an in-creased prevalence of ANA in the oldest-old, and emphasize the importance of taking gender and age into consideration when evaluating ANA.

Skogh, Thomas,1952-Östergötlands Läns Landsting,Linköpings universitet,Reumatologi,Hälsouniversitetet,Länskliniken för Reumatologi i Östergötland(Swepub:liu)thosk00 (författare)
Ernerudh, Jan,1952-Östergötlands Läns Landsting,Linköpings universitet,Klinisk immunologi,Hälsouniversitetet,Klinisk immunologi och transfusionsmedicin(Swepub:liu)janer15 (författare)
Johansson, BooGothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology,Department of Psychology, Göteborg University, Göteborg, Sweden(Swepub:gu)xjoboo (författare)
Lofgren, SDepartment of Microbiology, Ryhov Hospital, Jönköping, Sweden (författare)
Wikby, AInstitute of Gerontology, School of Health Sciences, Jönköping, Sweden (författare)
Dahle, Charlotte,1956-Linköpings universitet,Klinisk immunologi,Hälsouniversitetet(Swepub:liu)chada46 (författare)
Linköpings universitetInfektionsmedicin (creator_code:org_t)

Av författaren/redakt...: Nilsson, Bengt-O ...; Skogh, Thomas, 1 ...; Ernerudh, Jan, 1 ...; Johansson, Boo; Lofgren, S; Wikby, A; visa fler...; Dahle, Charlotte ...; visa färre...

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