Growth hormone-induced stimulation of swimming and feeding behaviour of rainbow trout is abolished by the D-1 dopamine antagonist SCH23390

Johansson, Viktoria,1972Gothenburg University,Göteborgs universitet,Zoologiska institutionen,Department of Zoology (författare)

The effects of GH on various types of behaviour in fish are well documented although the underlying mechanisms are not fully understood. In rainbow trout, an involvement of the brain dopaminergic system in mediating the behavioural effects of GH has been indicated, as GH can alter the brain doparninergic activity. To further examine the role of the dopaminergic system in the mediation of GH effects on locomotion and foraging, GH- and sham-implanted juvenile rainbow trout were injected with the selective D, dopamine antagonist SCH23390 or vehicle. Swimming and feeding activity was then studied by direct observation. Brains were thereafter sampled and analysed for the content of serotonin, dopamine and their metabolites in the hypothalamus, optic tecturn, cerebellum, telencephalon, and brain stem. GH increased swimming activity as well as feed intake, effects which were abolished by SCH23390. By itself, the antagonist did not affect behaviour, nor did it affect the brain monoamines. In contrast, treatment with GH, with or without SCH23390, decreased the content of the dopamine metabolite homovanillic acid (HVA) in the optic tecturn and the cerebellum, as well as the serotomin content (5-HT) in the optic tectum. It is concluded that the D-1 dopamine receptor of the dopaminergic system appears to be of importance in the mediation of the effects of GH on behaviour. (C) 2004 Elsevier Inc. All rights reserved.

NATURVETENSKAP Biologi hsv//swe
NATURAL SCIENCES Biological Sciences hsv//eng
growth hormone
behaviour
dopamine
d-1-receptors
sch23390
locomotor activity
swimming
feeding
monoamines
homovanillic acid
teleost fish
eel anguilla-anguilla
locomotor-activity
receptor subtypes
atlantic salmon
antipredator behavior
molecular-cloning
social-dominance
brain monoamines
increases
vertebrates
growth hormone; behaviour; dopamine; D-1-receptors; SCH23390; locomotor activity; swimming; feeding; monoamines; homovanillic acid; teleost fish

Winberg, SvanteUppsala universitet,Institutionen för fysiologi och utvecklingsbiologi,Jämförande fysiologi,jämförande fysiologi,fiskfysiologi(Swepub:uu)svanwinb (författare)
Björnsson, Björn Thrandur,1952Gothenburg University,Göteborgs universitet,Zoologiska institutionen,Department of Zoology(Swepub:gu)xbjorb (författare)
Göteborgs universitetZoologiska institutionen (creator_code:org_t)

Ingår i:General and Comparative Endocrinology: Elsevier BV141:1, s. 58-650016-6480

Av författaren/redakt...: Johansson, Vikto ...; Winberg, Svante; Björnsson, Björn ...

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