Prophylaxis against bone loss in kock reservoir patients with reduced glomerular filtration rate.

Jonsson, Olof,1941Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för urologi,Institute of Surgical Sciences, Department of Urology (author)

Objective We investigated whether treatment with calcium carbonate and vitamin D3 can improve the bone mineral content of patients with ileal reservoirs for continent urinary diversion and a reduced glomerular filtration rate (GFR). Material and methods Twenty-six patients with Kock reservoirs were included in the study. Bone mineralization was determined using dual-energy X-ray absorptiometry. Kidney function was estimated from Cr-EDTA clearance and serum cystatin C concentration. Osteocalcin and parathyroid hormone in serum were also measured. Patients with reduced GFR were treated with calcium carbonate and vitamin D3 perorally. Results Bone mineral density in the femur neck and hip increased in the treatment group, as reflected by an improved T score. Conclusion Patients with ileal reservoirs for continent urinary diversion and reduced kidney function should be supplemented with calcium carbonate and vitamin D3 in order to reduce the long-term risk of osteoporosis.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Urologi och njurmedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Urology and Nephrology hsv//eng
Bone mineralization; continent cutaneous urinary diversion; Cr-EDTA clearance; cystatin C; dual-energy X-ray absorptiometry; Kock reservoir; osteocalcin; parathyroid hormone

Herlitz, Hans,1946Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för njurmedicin,Institute of Internal Medicine, Dept of Nephrology(Swepub:gu)xherha (author)
Lindholm, Elisabet,1946Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery(Swepub:gu)xlelii (author)
Pazooki, David,1958Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för urologi,Institute of Surgical Sciences, Department of Urology (author)
Törnqvist, Harriet,1944Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery(Swepub:gu)xtorha (author)
Mellström, Dan,1945Gothenburg University,Göteborgs universitet,Institutionen för samhällsmedicin, Avdelningen för geriatrik,Institute of Community Medicine, Dept of Geriatric Medicine(Swepub:gu)xmelda (author)
Göteborgs universitetInstitutionen för de kirurgiska disciplinerna, Avdelningen för urologi (creator_code:org_t)

In:Scand J Urol Nephrol: Informa UK Limited39:3, s. 200-205
In:Scandinavian Journal of Urology and Nephrology: Informa UK Limited39:3, s. 200-2050036-55991651-2065

By the author/editor: Jonsson, Olof, 1 ...; Herlitz, Hans, 1 ...; Lindholm, Elisab ...; Pazooki, David, ...; Törnqvist, Harri ...; Mellström, Dan, ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Urology and Neph ...

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