Detection rates of high-grade prostate cancer during subsequent screening visits. Results of the European Randomized Screening Study for Prostate Cancer.

Screening for prostate cancer using prostate-specific antigen (PSA) tests has led to a stage and grade shift as compared to the pre-PSA era. Effectiveness of screening for prostate cancer should be manifested by a reduction in detection rate of aggressive cancers during subsequent screening. In 6 centers of the European Randomized Screening study for Prostate Cancer, a total of 58,710 men were tested for prostate cancer. Screening centers differed with regard to age-range, screening interval and biopsy indications. During the 2nd visit, the proportion of Gleason score 6 cancers increased from 62.5 to 75%, mainly at the expense of Gleason score 7 cancers. High-grade (Gleason score 8-10) cancer detection rates varied per screening center during the 1st visit from 5.1 to 41.1, and during the 2nd visit from 6.4 to 29.3/10,000 men. The overall detection rate of high-grade cancers showed a reduction during the 2nd visit from 26 to 12/10,000 men, an effect mainly attributable to the screening center with the highest cancer detection rate (i.e. 507/10,000 men). Variations in detection rates among screening centers related among others to biopsy compliance and age range.

Ciatto, S (författare)
Martikainen, PH (författare)
Hoedemaeker, R (författare)
Laurila, M (författare)
Pihl, Carl GustafGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences (författare)
Hugosson, Jonas,1955Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xhugjo (författare)
Neetens, I (författare)
Nelen, V (författare)
Di Lollo, S (författare)
Roobol, MJ (författare)
Maatanen, L (författare)
Santonja, S (författare)
Moss, S (författare)
Schröder, FH (författare)
Göteborgs universitetInstitutionen för kliniska vetenskaper (creator_code:org_t)

Ingår i:Int J Cancer: Wiley118:10, s. 2538-2542
Ingår i:International Journal of Cancer: Wiley118:10, s. 2538-25420020-71361097-0215

Av författaren/redakt...: van der Kwast, T ...; Ciatto, S; Martikainen, PH; Hoedemaeker, R; Laurila, M; Pihl, Carl Gusta ...; visa fler...; Hugosson, Jonas, ...; Neetens, I; Nelen, V; Di Lollo, S; Roobol, MJ; Maatanen, L; Santonja, S; Moss, S; Schröder, FH; visa färre...

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