Sökning: WFRF:(Sabina S)
> (2001-2004) >
Leukotriene and pro...
Leukotriene and prostanoid pathway enzymes in bronchial biopsies of seasonal allergic asthmatics
-
Seymour, M. L. (författare)
-
- Rak, Sabina, 1945 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
-
- Åberg, Daniel, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
-
visa fler...
-
- Riise, Gerdt C., 1956 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för lungmedicin och allergologi,Institute of Internal Medicine, Dept of Respiratory Medicine/Allergology
-
Penrose, J. F. (författare)
-
Kanaoka, Y. (författare)
-
Austen, K. F. (författare)
-
Holgate, S. T. (författare)
-
Sampson, A. P. (författare)
-
visa färre...
-
(creator_code:org_t)
- 2001
- 2001
- Engelska.
-
Ingår i: Am J Respir Crit Care Med. - 1073-449X. ; 164:11, s. 2051-6
- Relaterad länk:
-
https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- Cysteinyl-leukotrienes and prostaglandin D2 generated by the 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways, respectively, cause bronchoconstriction, leukocyte recruitment, and bronchial hyperresponsiveness in asthma. We characterized the cellular expression of 5-LO and COX enzymes using immunohistochemistry on bronchial biopsies from 12 allergic asthmatic patients before and during seasonal exposure to birch pollen. Bronchial responsiveness (p = 0.004) and symptoms (p < 0.005) increased and peak expiratory flow (PEF; p < or = 0.02) decreased in the pollen season. In-season biopsies had 2-fold more cells immunostaining for 5-LO (p = 0.02), 5-LO-activating protein (FLAP; p = 0.04), and leukotriene (LT)A4 hydrolase (p = 0.05), and 4-fold more for the terminal enzyme for cysteinyl-leukotriene synthesis, LTC4 synthase (p = 0.02). Immunostaining for COX-1, COX-2, and PGD2 synthase was unchanged. Increased staining for LTC4 synthase was due to increased eosinophils (p = 0.035) and an increased proportion of eosinophils expressing the enzyme (p = 0.047). Macrophages also increased (p = 0.019), but mast cells and T-lymphocyte subsets were unchanged. Inverse correlations between PEF and 5-LO(+) cell counts link increased expression of 5-LO pathway enzymes in eosinophils and macrophages within the bronchial mucosa to deterioration of lung function during seasonal allergen exposure.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Nyckelord
- Adult
- Air Pollution/adverse effects/analysis
- Arachidonate 5-Lipoxygenase/*analysis/immunology/*metabolism
- Asthma/etiology/*metabolism/*pathology/physiopathology
- Biopsy
- Bronchial Hyperreactivity/etiology/*metabolism/*pathology/physiopathology
- Eosinophils/immunology
- Forced Expiratory Volume
- Humans
- Hypersensitivity/etiology/*metabolism/*pathology/physiopathology
- Immunohistochemistry
- Leukocyte Count
- Leukotrienes/*analysis/immunology/*metabolism
- Macrophages/immunology
- Mast Cells/immunology
- Peak Expiratory Flow Rate
- Pollen/*adverse effects
- Prostaglandin-Endoperoxide Synthases/*analysis/immunology/*metabolism
- Prostaglandins/*analysis/immunology/*metabolism
- *Seasons
- Severity of Illness Index
- Sweden
- T-Lymphocytes/immunology
- Trees
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Seymour, M. L.
-
Rak, Sabina, 194 ...
-
Åberg, Daniel, 1 ...
-
Riise, Gerdt C., ...
-
Penrose, J. F.
-
Kanaoka, Y.
-
visa fler...
-
Austen, K. F.
-
Holgate, S. T.
-
Sampson, A. P.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Dermatologi och ...
- Artiklar i publikationen
-
Am J Respir Crit ...
- Av lärosätet
-
Göteborgs universitet