id:"swepub:oai:gup.ub.gu.se/45507"
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- Elmroth, Kerstin,1970Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för onkologi,Institute of Selected Clinical Sciences, Department of Oncology (author)
Radiation and hypothermia: changes in DNA supercoiling in human diploid fibroblasts
- Article/chapterEnglish1999
Publisher, publication year, extent ...
- 1999
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- LIBRIS-ID:oai:gup.ub.gu.se/45507
- https://gup.ub.gu.se/publication/45507URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-22306URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:1958335URI
Supplementary language notes
- Language:English
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Notes
- The influence of hypothermia (2 degrees, 15 degrees and 28 degrees C) upon the effect of X-irradiation on chromatin from human diploid fibroblast cells (AG1518) was studied using the fluorescent halo assay. Rewinding of supercoils was inhibited in a dose-dependent manner when cells were irradiated with 4, 8 or 16 Gy. This inhibition of rewinding was reduced when cells were irradiated at subnormal temperatures compared with cells irradiated at 37 degrees C. One hour's preincubation at low temperature did not influence rewinding. When AG1518 cells were irradiated at 37 degrees C in the presence of the radical scavenger DMSO (0.5 M), the radiation-induced damage was reduced. No additional protection of DMSO in hypothermic cells (2 degrees C) was found, possibly indicating that OH-radical-mediated effects are more temperature dependent. These results are similar to those recently found for the malignant MCF-7 cell line.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- NATURVETENSKAP Biologi hsv//swe
- NATURAL SCIENCES Biological Sciences hsv//eng
- *Cold
- DNA
- Superhelical/chemistry/*radiation effects
- Dimethyl Sulfoxide/chemistry
- *Diploidy
- Fibroblasts/metabolism
- Free Radical Scavengers/chemistry
- Humans
- Nucleic Acid Conformation/*radiation effects
- radiation
Added entries (persons, corporate bodies, meetings, titles ...)
- Erkell, L. J. (author)
- Nygren, JonasSödertörns högskola,Avdelning Naturvetenskap,Karolinska Institute(Swepub:sh)SHJSNN (author)
- Hultborn, Ragnar,1946Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för onkologi,Institute of Selected Clinical Sciences, Department of Oncology(Swepub:gu)xhulra (author)
- Göteborgs universitetInstitutionen för särskilda specialiteter, Avdelningen för onkologi (creator_code:org_t)
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- In:Anticancer Res19:6B, s. 5307-110250-70051791-7530
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