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Chromogranin A as a...
Chromogranin A as a determinant of midgut carcinoid tumour volume
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- Kölby, Lars, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery
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- Bernhardt, Peter, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för radiofysik,Institute of Selected Clinical Sciences, Department of Radiation Physics
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- Swärd, Christina, 1967 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery
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- Johanson, Viktor, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery
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- Ahlman, Håkan, 1947 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery
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- Forssell-Aronsson, Eva, 1961 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för radiofysik,Institute of Selected Clinical Sciences, Department of Radiation Physics
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- Stridsberg, Mats (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Clinical Chemistry
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- Wängberg, Bo, 1953 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery
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- Nilsson, Ola, 1957 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin , Avdelningen för patologi,Institute of Laboratory Medicine, Dept of Pathology
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(creator_code:org_t)
- Elsevier BV, 2004
- 2004
- English.
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In: Regulatory peptides. - : Elsevier BV. - 0167-0115. ; 120:1-3, s. 269-73
- Related links:
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http://www.ncbi.nlm....
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Neuroendocrine (NE) tumours are characterized by their capacity to synthesize, store and release hormonal products. These substances are stored in neurosecretory vesicles together with chromogranin A (CgA). The concentration of plasma CgA in patients with NE tumours is thought to reflect the degree of NE differentiation, total tumour burden and effect of medical treatment. The aim of this study was to analyse the correlation between tumour weight and plasma CgA levels as well as the influence of treatment with a long-acting somatostatin analogue (octreotide) using nude mice with xenografted human ileal carcinoid tumours. There was a correlation between tumour weight and plasma CgA levels in all animals (p < 0.00001). In octreotide-treated mice, plasma CgA levels were significantly reduced versus untreated animals (p = 0.037). In conclusion, this study demonstrates that plasma CgA levels are closely correlated to tumour burden, and that plasma CgA is well suited for monitoring the clinical course and outcome of treatment in patients with NE tumours.
Keyword
- Animals
- Carcinoid Tumor/*diagnosis/drug therapy/metabolism
- Chromogranin A
- Chromogranins/*blood
- Gastrointestinal Agents/*therapeutic use
- Humans
- Ileal Neoplasms/*diagnosis/drug therapy/metabolism
- Male
- Mice
- Mice
- Inbred BALB C
- Mice
- Nude
- Octreotide/*therapeutic use
- Transplantation
- Heterologous
- Treatment Outcome
- Tumor Burden
- Tumor Markers
- Biological/analysis/*blood
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kölby, Lars, 196 ...
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Bernhardt, Peter ...
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Swärd, Christina ...
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Johanson, Viktor ...
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Ahlman, Håkan, 1 ...
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Forssell-Aronsso ...
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Stridsberg, Mats
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Wängberg, Bo, 19 ...
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Nilsson, Ola, 19 ...
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- Articles in the publication
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Regulatory pepti ...
- By the university
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University of Gothenburg
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Uppsala University