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Actions by angioten...
Actions by angiotensin II on esophageal contractility in humans
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- Casselbrant, Anna, 1970 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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- Edebo, Anders, 1968 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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- Wennerblom, Johanna, 1969 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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- Lönroth, Hans, 1952 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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- Helander, Herbert F, 1935 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Vieth, M. (författare)
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- Lundell, L. (författare)
- Karolinska Institutet
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- Fändriks, Lars, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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(creator_code:org_t)
- Elsevier BV, 2007
- 2007
- Engelska.
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Ingår i: Gastroenterology. - : Elsevier BV. - 0016-5085. ; 132:1, s. 249-60
- Relaterad länk:
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https://gup.ub.gu.se...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND & AIMS: Angiotensin II is a potent activator of smooth muscles but has not been much investigated with regard to gastrointestinal motor activity. This study explores expression of the renin-angiotensin system (RAS) in human esophageal musculature and actions by Angiotensin II both in vitro and in vivo. METHODS: Muscular specimens of esophageal body and lower esophageal sphincter were obtained from patients undergoing resection as a result of mucosal neoplasm. Healthy volunteers participated in functional examinations of esophageal motility assessed by high-resolution manometry and multiple transmucosal potential-difference measurements. RESULTS: Gene transcripts of key components of RAS were found in the esophageal musculature. Immunohistochemistry revealed a distinct staining for Angiotensin II type 1 (AT(1)) receptors in the muscular bundles and blood-vessel walls, whereas Angiotensin II type 2 receptors were confined to blood vessels only. Angiotensin II caused concentration-dependent contractions in vitro, which were inhibited by the AT(1) receptor antagonist losartan but not by the Angiotensin II type 2 receptor antagonist PD123319. Administration of the AT(1) receptor antagonist candesartan reduced the amplitude of swallow-induced peristaltic contractions and both the length and pressure amplitude of baseline high-pressure zone at the esophagogastric junction. Neither swallow-induced axial movements, nor the contraction after transient lower esophageal sphincter relaxations, were influenced by candesartan pretreatment. CONCLUSIONS: The study demonstrates a local RAS in the musculature of the distal esophagus and that Angiotensin II is a potent stimulator of esophageal contractions via the AT(1) receptor. The results suggest that Angiotensin II participates in the physiological control of the human esophageal motor activity.
Nyckelord
- Aged
- Aged
- 80 and over
- Angiotensin II/*pharmacology
- Angiotensin II Type 1 Receptor Blockers/administration & dosage
- Angiotensinogen/genetics
- Benzimidazoles/administration & dosage
- Esophageal Sphincter
- Lower/*physiology
- Esophagus/*physiology
- Female
- Gene Expression
- Humans
- Male
- Manometry
- Middle Aged
- Muscle Contraction/*drug effects
- Peptidyl-Dipeptidase A/genetics
- Peristalsis/drug effects
- Receptor
- Angiotensin
- Type 1/genetics/metabolism
- Receptor
- Angiotensin
- Type 2/genetics/metabolism
- Renin/genetics/metabolism
- Tetrazoles/administration & dosage
- Vasoconstrictor Agents/*pharmacology
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- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Casselbrant, Ann ...
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Edebo, Anders, 1 ...
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Wennerblom, Joha ...
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Lönroth, Hans, 1 ...
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Helander, Herber ...
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Vieth, M.
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Lundell, L.
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Fändriks, Lars, ...
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- Artiklar i publikationen
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Gastroenterology
- Av lärosätet
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Göteborgs universitet
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Karolinska Institutet