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Changes in weight w...
Changes in weight with depot medroxyprogesterone acetate subcutaneous injection 104 mg/0.65 mL
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Westhoff, C (författare)
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Jain, J K (författare)
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- Milsom, Ian, 1950 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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visa fler...
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Ray, A (författare)
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visa färre...
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(creator_code:org_t)
- 2007
- 2007
- Engelska.
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Ingår i: Contraception. ; 75:4, s. 261-7
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- INTRODUCTION: The study was conducted to assess the impact of depot medroxyprogesterone acetate subcutaneous injection 104 mg/0.65 mL (DMPA-SC 104) on body weight. METHODS: Changes in weight from pretreatment were analyzed using data from two 1-year, noncomparative trials of DMPA-SC 104 (North/South American, N=722; European/Asian, N=1065) and a 3-year, randomized study (SC/IM) comparing DMPA-SC 104 (N=266) with the DMPA intramuscular injection 150 mg/mL (DMPA-IM 150). For each study, additional analyses were conducted for changes in body weight by age (<25, 25 to 35 and >35 years) and body mass index (BMI) (25 to 30 kg/m2) subgroups. RESULTS: In both 1-year trials, the mean (+/-SD) weight gain at month 12 was <2 kg [1.7 kg (+/-4.5 SD) in the Americas trial and 1.4 kg (+/-3.6 SD) in the Europe/Asia trial]. In the SC/IM trial, mean weight changes were similar between DMPA-SC 104 and DMPA-IM 150 groups, with mean (+/-SD) gains at month 36 of 4.5+/-8.5 and 5.8+/-8.7 kg, respectively. Similar differences in weight gain were observed by age or baseline BMI in all studies. CONCLUSION: DMPA-SC 104 was associated with modest weight gain in most women.
Nyckelord
- Adult
- Age Factors
- Body Mass Index
- Contraceptive Agents
- Female/administration & dosage/*pharmacology
- Female
- Humans
- Injections
- Subcutaneous
- Medroxyprogesterone 17-Acetate/administration & dosage/*pharmacology
- Middle Aged
- Weight Gain/*drug effects
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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