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Global gene express...
Global gene expression in the immature brain after hypoxia-ischemia
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- Hedtjärn, Maj, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology
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- Mallard, Carina, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology
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- Eklind, Saskia (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för obstetrik och gynekologi,Institute for the Health of Women and Children, Dept of Obstetrics and Gynaecology
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- Gustafsson Brywe, Katarina, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för obstetrik och gynekologi,Institute for the Health of Women and Children, Dept of Obstetrics and Gynaecology
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- Hagberg, Henrik, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för obstetrik och gynekologi,Institute for the Health of Women and Children, Dept of Obstetrics and Gynaecology
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(creator_code:org_t)
- 2004
- 2004
- English.
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In: J Cereb Blood Flow Metab. ; 24:12, s. 1317-32
- Related links:
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https://gup.ub.gu.se...
Abstract
Subject headings
Close
- Ischemia induces a complex response of differentially expressed genes in the brain. In order to understand the specific mechanisms of injury in the developing brain, it is important to obtain information on global changes in the transcriptome after neonatal hypoxia-ischemia. In this study, oligonucleotide arrays were used to investigate genomic changes at 2, 8, 24, and 72 hours after neonatal hypoxia-ischemia, which was induced in 9-day-old mice by left carotid artery ligation followed by hypoxia (10% O2). In total, 343 genes were differentially expressed in cortex, hippocampus, thalamus, and striatum 2 to 72 hours after hypoxia-ischemia, when comparing ipsilateral with contralateral hemispheres and with controls, using the significance analysis for microarrays. A total of 283 genes were upregulated and 60 were downregulated, and 94% of the genes had not previously been shown after neonatal hypoxia-ischemia. Genes related to transcription factors and metabolism had mostly upregulated transcripts, whereas most downregulated genes belonged to the categories of ion and vesicular transport and signal transduction. Genes involved in transcription, stress, and apoptosis were induced early after the insult, and many new genes that may play important roles in the pathophysiology of neonatal hypoxia-ischemia were identified.
Keyword
- Aging/*genetics
- Animals
- Animals
- Newborn
- Apoptosis/genetics
- Cytoskeleton/genetics
- *Gene Expression Profiling
- Gene Expression Regulation
- Growth Substances/genetics
- Hormones/genetics
- Hypoxia-Ischemia
- Brain/*genetics
- Mice
- Mice
- Inbred C57BL
- Neurotransmitter Agents/genetics
- Oligonucleotide Array Sequence Analysis
- Protein Transport
- RNA
- Messenger/analysis/genetics
- Signal Transduction
- Stress/genetics
- Synapses/genetics
- Transcription
- Genetic/genetics
Publication and Content Type
- ref (subject category)
- art (subject category)
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