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Augmented levels of...
Augmented levels of CD44 in macrophages from atherosclerotic subjects: a possible IL-6-CD44 feedback loop?
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- Hägg, Daniel, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg,Research Center for Endocrinology and Metabolism, Department of Metabolism and Cardiovascular Research, Göteborg, Sweden
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- Sjöberg, Sara, 1979 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg,Research Center for Endocrinology and Metabolism, Department of Metabolism and Cardiovascular Research, Göteborg, Sweden
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- Mattsson Hultén, Lillemor, 1951 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,University of Gothenburg,Wallenberg Laboratory for Cardiovascular Research, Department of Metabolism and Cardiovascular Research, Göteborg, Sweden
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- Fagerberg, Björn, 1943 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg,Wallenberg Laboratory for Cardiovascular Research, Department of Metabolism and Cardiovascular Research, Göteborg, Sweden
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- Wiklund, Olov, 1943 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg,Wallenberg Laboratory for Cardiovascular Research, Department of Metabolism and Cardiovascular Research, Göteborg, Sweden
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- Rosengren, Annika, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för akut och kardiovaskulär medicin,Institute of Medicine, Department of Emergeny and Cardiovascular Medicine,University of Gothenburg,Department of Acute and Cardiovascular Medicine, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden
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- Carlsson, Lena M S, 1957 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Borén, Jan, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory,University of Gothenburg,Wallenberg Laboratory for Cardiovascular Research, Department of Metabolism and Cardiovascular Research, Göteborg, Sweden
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- Svensson, Per-Arne, 1969 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg,Research Center for Endocrinology and Metabolism, Department of Metabolism and Cardiovascular Research, Göteborg, Sweden / Wallenberg Laboratory for Cardiovascular Research, Department of Metabolism and Cardiovascular Research, Göteborg, Sweden
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- Krettek, Alexandra, 1968 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,University of Gothenburg,Wallenberg Laboratory for Cardiovascular Research, Department of Metabolism and Cardiovascular Research, Göteborg, Sweden
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(creator_code:org_t)
- Elsevier BV, 2007
- 2007
- English.
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In: Atherosclerosis. - : Elsevier BV. - 0021-9150 .- 1879-1484. ; 190:2, s. 291-7
- Related links:
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https://doi.org/10.1...
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Abstract
Subject headings
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- The cell-adhesion molecule CD44 likely participates in atherosclerosis development. We have shown previously that pro-inflammatory cytokines affect CD44 expression. Therefore, this work examined the role of elevated CD44 levels in human macrophages. Macrophages from human atherosclerotic subjects (n=15) showed elevated levels of CD44 transcript and protein (1.5-fold) compared to matched controls (n=15) (P=0.050 and 0.044, respectively). To test whether genetic factors influence CD44 expression, two single nucleotide polymorphisms in the CD44 gene were analyzed but these were not associated with coronary artery disease. We also examined the potential connection between plasma cytokine levels and CD44 expression. In atherosclerotic subjects, elevated CD44 expression correlates (P=0.012) with enhanced macrophage IL-6 secretion (3.13+/-2.5 pg/mL versus 0.32+/-0.16 pg/mL in controls, P=0.021). Additionally, CD44-deficient mice exhibit less circulating IL-6 than wild-type controls (9.8+/-0.7 pg/mL versus 14.3+/-0.7 pg/mL; P=0.032). Furthermore, IL-6 augments CD44 expression in primary human macrophages after 24 h (P=0.038) and 48 h (P=0.015). Taken together, our data show an IL-6-CD44 feedback loop in macrophages. Such a positive feedback loop may aggravate atherosclerosis development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Andra medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Other Basic Medicine (hsv//eng)
Keyword
- Animals
- Antigens
- CD/genetics/immunology
- Antigens
- CD44/*genetics
- Atherosclerosis/blood/genetics/*immunology
- Coronary Disease/genetics/immunology
- Cytokines/blood
- Feedback
- Humans
- Interleukin-6/*blood/genetics
- Macrophages/*immunology/pathology
- Mice
- Nucleic Acid Hybridization
- Oligonucleotide Array Sequence Analysis
- *Polymorphism
- Single Nucleotide
- Reverse Transcriptase Polymerase Chain Reaction
- Coronary Disease/genetics/immunology
- Medical sciences
Publication and Content Type
- ref (subject category)
- art (subject category)
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Hägg, Daniel, 19 ...
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Sjöberg, Sara, 1 ...
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Mattsson Hultén, ...
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Fagerberg, Björn ...
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Wiklund, Olov, 1 ...
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Rosengren, Annik ...
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Carlsson, Lena M ...
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Borén, Jan, 1963
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Svensson, Per-Ar ...
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Krettek, Alexand ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Other Basic Medi ...
- Articles in the publication
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Atherosclerosis
- By the university
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University of Gothenburg
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Chalmers University of Technology
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University of Skövde