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  • Bonduelle, M (author)

A multi-centre cohort study of the physical health of 5-year-old children conceived after intracytoplasmic sperm injection, in vitro fertilization and natural conception

  • Article/chapterEnglish2005

Publisher, publication year, extent ...

  • 2005

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/49686
  • https://gup.ub.gu.se/publication/49686URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND: Over a million children have been born from assisted conception worldwide. Newer techniques being introduced appear less and less 'natural', such as intracytoplasmic sperm injection (ICSI), but there is little information on these children beyond the neonatal period. METHODS: 540 ICSI conceived 5-year-old children from five European countries were comprehensively assessed, along with 538 matched naturally conceived children and 437 children conceived with standard IVF. RESULTS: Of the 540 ICSI children examined, 63 (4.2%) had experienced a major congenital malformation. Compared with naturally conceived children, the odds of a major malformation were 2.77 (95% CI 1.41-5.46) for ICSI children and 1.80 (95% CI 0.85-3.81) for IVF children; these estimates were little affected by adjustment for socio-demographic factors. The higher rate observed in the ICSI group was due partially to an excess of malformations in the (boys') urogenital system. In addition, ICSI and IVF children were more likely than naturally conceived children to have had a significant childhood illness, to have had a surgical operation, to require medical therapy and to be admitted to hospital. A detailed physical examination revealed no further substantial differences between the groups, however. CONCLUSIONS: Singleton ICSI and IVF 5-year-olds are more likely to need health care resources than naturally conceived children. Assessment of singleton ICSI and IVF children at 5 years of age was generally reassuring, however, we found that ICSI children presented with more major congenital malformations and both ICSI and IVF children were more likely to need health care resources than naturally conceived children. Ongoing monitoring of these children is therefore required.

Subject headings and genre

  • Abnormalities/*epidemiology
  • Child
  • Preschool
  • Cohort Studies
  • Europe/epidemiology
  • Female
  • *Fertilization
  • Fertilization in Vitro/*statistics & numerical data
  • *Health Status
  • Hospitalization/statistics & numerical data
  • Humans
  • Male
  • Maternal Age
  • Morbidity
  • Paternal Age
  • Physical Examination
  • Sperm Injections
  • Intracytoplasmic/*statistics & numerical data

Added entries (persons, corporate bodies, meetings, titles ...)

  • Wennerholm, Ulla-Britt,1948Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för obstetrik och gynekologi,Institute for the Health of Women and Children, Dept of Obstetrics and Gynaecology(Swepub:gu)xwennu (author)
  • Loft, A (author)
  • Tarlatzis, B C (author)
  • Peters, C (author)
  • Henriet, S (author)
  • Mau, C (author)
  • Victorin Cederqvist, AGothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för obstetrik och gynekologi,Institute for the Health of Women and Children, Dept of Obstetrics and Gynaecology (author)
  • Van Steirteghem, A (author)
  • Balaska, A (author)
  • Emberson, J R (author)
  • Sutcliffe, A G (author)
  • Göteborgs universitetInstitutionen för kvinnors och barns hälsa, Avdelningen för obstetrik och gynekologi (creator_code:org_t)

Related titles

  • In:Hum Reprod20:2, s. 413-9

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