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Hypoxia increases L...
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Knutsen Rydberg, Ellen,1969Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,Wallenberg Lab. for Cardiovasc. Res., Sahlgrenska University Hospital, Göteborg, Sweden
(author)
Hypoxia increases LDL oxidation and expression of 15-lipoxygenase-2 in human macrophages
- Article/chapterEnglish2004
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Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/49802
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https://gup.ub.gu.se/publication/49802URI
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https://doi.org/10.1161/01.ATV.0000144951.08072.0bDOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-11388URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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OBJECTIVE: Macrophage-mediated oxidation of low-density lipoprotein (LDL) by enzymes, such as the lipoxygenases, is considered of major importance for the formation of oxidized LDL during atherogenesis. Macrophages have been identified in hypoxic areas in atherosclerotic plaques. METHODS AND RESULTS: To investigate the role of hypoxia in macrophage-mediated LDL oxidation, we incubated human monocyte-derived macrophages with LDL under normoxic (21% O2) or hypoxic (0% O2) conditions. The results showed that hypoxic macrophages oxidized LDL to a significantly higher extent than normoxic cells. Interestingly, the mRNA and protein expression of 15-lipoxygenase-2 (15-LOX-2) as well as the activity of this enzyme are elevated in macrophages incubated at hypoxia. Both the unspliced 15-LOX-2 and the spliced variant 15-LOX-2sv-a are found in macrophages. In addition, 15-LOX-2 was identified in carotid plaques in some macrophage-rich areas but was only expressed at low levels in nondiseased arteries. CONCLUSIONS: In summary, these observations show for the first time that 15-LOX-2 is expressed in hypoxic macrophages and in atherosclerotic plaques and suggest that 15-LOX-2 may be one of the factors involved in macrophage-mediated LDL oxidation at hypoxia.
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Krettek, Alexandra,1968Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,Wallenberg Lab. for Cardiovasc. Res., Sahlgrenska University Hospital, Göteborg, Sweden(Swepub:his)krea
(author)
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Ullström, Christina,1950Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,Wallenberg Lab. for Cardiovasc. Res., Sahlgrenska University Hospital, Göteborg, Sweden(Swepub:gu)xullch
(author)
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Ekström, Karin,1977Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,Wallenberg Lab. for Cardiovasc. Res., Sahlgrenska University Hospital, Göteborg, Sweden(Swepub:gu)xekkar
(author)
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Svensson, Per-Arne,1969Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism,Res. Ctr. for Endocrinol./Metabolism, Sahlgrenska Univ. Hospital, Göteborg, Sweden(Swepub:gu)xsvper
(author)
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Carlsson, Lena M S,1957Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism,Res. Ctr. for Endocrinol./Metabolism, Sahlgrenska Univ. Hospital, Göteborg, Sweden(Swepub:gu)xcarle
(author)
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Jönsson-Rylander, Ann-Christine
(author)
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Hansson, G.IBioanalytical Chemistry, AstraZeneca R and D, Mölndal, Sweden
(author)
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McPheat, W.Molecular Pharmacology and DMPK, AstraZeneca R and D, Mölndal, Sweden
(author)
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Wiklund, Olov,1943Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Wallenberglaboratoriet,Cardiovascular Institute,Wallenberg Laboratory,Wallenberg Lab. for Cardiovasc. Res., Sahlgrenska University Hospital, Göteborg, Sweden(Swepub:gu)xwikol
(author)
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Ohlsson, Bertil,1954Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,Wallenberg Lab. for Cardiovasc. Res., Sahlgrenska University Hospital, Göteborg, Sweden(Swepub:gu)xohlbe
(author)
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Mattsson Hultén, Lillemor,1951Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,Wallenberg Lab. for Cardiovasc. Res., Sahlgrenska University Hospital, Göteborg, Sweden(Swepub:gu)xmatli
(author)
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Jönsson-Rylander, Ann-CathrineMolecular Pharmacology and DMPK, AstraZeneca R and D, Mölndal, Sweden
(author)
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Göteborgs universitetWallenberglaboratoriet
(creator_code:org_t)
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